Retinoid roles in blocking hepatocellular carcinoma.
Retinoid roles in blocking hepatocellular carcinoma.
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DOI：
10.3978/j.issn.2304-3881.2015.05.01
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发表时间：
2015-11
影响因子：
8
通讯作者：
Y. Shirakami;Hiroyasu Sakai-;M. Shimizu
中科院分区：
文献类型：
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作者：
Y. Shirakami;Hiroyasu Sakai-;M. Shimizu
肝细胞癌（HCC）是许多国家的主要健康问题。由于HCC的高复发率和化疗耐药性，其预后仍然较差。人们早就知道类维生素A与肝病（包括肝癌）有关。许多实验和临床研究已证明类维生素A与肝脏疾病之间的关联，包括HCC细胞系中类维生素A活性的丧失、肝硬化和HCC患者中类维生素A储存量的减少以及类维生素A信号传导的改变。基于这些发现，已经开展了类视黄醇对 HCC 影响的临床前和临床研究。最近，发表了使用合成类维生素A、无环类维生素A（ACR）预防HCC复发的临床试验结果。此外，还对类视黄醇在肝病中的作用进行了广泛的实验研究，包括慢性病毒性肝炎和导致肝癌的非酒精性脂肪肝病（NAFLD）。在本综述的第一部分中，我们将总结类视黄醇治疗肝病和阻断 HCC 的有效性和作用。随后，我们将重点关注 ACR 阻断 HCC 的行动。
Hepatocellular carcinoma (HCC) is a major health issue in many countries. The prognosis of HCC is still poor due to its high recurrence rate and its resistance to chemotherapy. Retinoids have long been known to have a connection with liver diseases, including HCC. Many experimental and clinical investigations have demonstrated associations between retinoids and hepatic disease, including the loss of retinoid activity in HCC cell lines and decreased hepatic retinoid stores and altered retinoid signaling in patients with cirrhosis and HCC. Based on these findings, preclinical and clinical investigations of retinoid effects on HCC have been undertaken. Recently, clinical trial results for the use of a synthetic retinoid, acyclic retinoid (ACR), to prevent HCC recurrence were published. In addition, extensive experimental studies on the action of retinoids in liver disease, including chronic viral hepatitis and non-alcoholic fatty liver disease (NAFLD), which lead to HCC have been performed. In the first section of this review, we will summarize the effectiveness and roles of retinoid for treating liver disease and blocking HCC. Subsequently, we will focus on ACR actions in blocking HCC.