A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States).
A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States).
复制标题
表征金属加工液暴露和前列腺癌风险的生物学方法（美国）。
DOI：
10.1007/s10552-004-4323-7
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Wegman,DavidH
中科院分区：
文献类型：
--
作者：
Agalliu,Ilir;Eisen,EllenA;Kriebel,David;Quinn,MargaretM;Wegman,DavidH
目的：前列腺癌是一种与激素相关的疾病，干扰激素的化学物质可能参与前列腺癌的发生。在一个队列的汽车工人，我们的特点是暴露于金属加工液（MWF）到年龄窗口同质的前列腺癌的生物风险，并检查使用半参数modeling.Methods的发病率-反应关系：事件的情况下（n=872）确定通过密歇根州癌症登记处从1985年到2000年。使用发病率-密度采样（5：1比率）选择对照。使用基于年龄的模型，在三个窗口中累积暴露量：（1）青春期后期，（2）成年期和（3）中年期。我们使用惩罚样条模型的风险作为一个平滑的函数的曝光，并控制种族和日历年的诊断在一个考克斯model.Results：前列腺癌的风险线性增加，暴露于直MWF在第一个窗口，与2.4每10毫克/立方米年的相对风险。汽车工人在年轻时接触MWF也有增加的风险与MWF暴露发生在以后的生活。对于可溶性MWF有一个轻微增加的风险在third windows.Conclusions：暴露表征激素模型的基础上，确定了风险增高与早期暴露于直MWF。结果还支持暴露相关前列腺癌的长潜伏期。
Objective: Prostate cancer is hormone-related and chemicals that interfere with hormones may contribute to carcinogenesis. In a cohort of autoworkers we characterized exposure to metalworking fluids (MWF) into age windows with homogenous biological risk for prostate cancer, and examined exposure–response relationships using semi-parametric modeling.Methods: Incident cases (n=872) were identified via Michigan cancer registry from 1985 through 2000. Controls were selected using incidence-density sampling, 5:1 ratio. Using a hormonal-based model, exposure was accumulated in three windows: (1) late puberty, (2) adulthood, and (3) middle age. We used penalized splines to model risk as a smooth function of exposure, and controlled for race and calendar year of diagnosis in a Cox model.Results: Risk of prostate cancer linearly increased with exposure to straight MWF in the first window, with a relative risk of 2.4 per 10 mg/m3-years. Autoworkers exposed to MWF at a young age also had an increased risk associated with MWF exposure incurred later in life. For soluble MWF there was a slightly increased risk in the third window.Conclusions: Exposure characterization based on a hormonal model identified heightened risk with early age of exposure to straight MWF. Results also support a long latency period for exposure related prostate cancer.