Cytochrome P450 enzyme polymorphism frequency in indigenous and native American populations: A systematic review
Cytochrome P450 enzyme polymorphism frequency in indigenous and native American populations: A systematic review
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DOI：
10.1159/000113876
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Veenstra, David L.
中科院分区：
文献类型：
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作者：
Jaja, Cheedy;Burke, Wylie;Veenstra, David L.
目的：本研究的目的是评估细胞色素P450酶基因多态在美洲半球土著人群中作为潜在遗传因素影响药物疗效和安全性的证据。方法：我们利用Pubmed数据库对1985至2006年间发表的研究进行了系统回顾。结果：在13个美洲原住民群体中，我们只发现了10项关于CYP2A6、CYP2D6、CYP2C9、CYP2C19和CYP2E1的原创研究。在所研究的土著人口中以及与非洲、亚洲和欧洲人口的比较中，细胞色素P450基因变异的频率存在种族间差异。结论：令人惊讶的是，美国原住民群体中关于CYP450酶基因多态性的数据很少，而且很难得出任何明确的推论，说明这些群体与其他种族或民族群体可能对药物有什么反应。这种信息的缺乏可能会对在这些人群中使用药物遗传学测试造成障碍。需要土著社区和研究人员之间的合作伙伴关系，才能使CYP450酶多态检测对土著人口产生临床益处。版权所有(C)2008 S.Karger AG，巴塞尔。
Objective:The purpose of our study was to evaluate the evidence on the prevalence of cytochrome P450 enzyme polymorphisms as potential genetic factors influencing drug efficacy and safety in the indigenous populations of the American hemispheres. Methods: We conducted a systematic review of studies published between 1985 and 2006 using the Pubmed database. Results: We identified only 10 original research studies on CYP2A6, CYP2D6, CYP2C9, CYP2C19and CYP2E1 in 13 indigenous American populations. Interethnic differences in the frequency of CYP450 genetic variants existed both among the examined indigenous populations and in comparison with African, Asian and European populations. Conclusions: There are surprisingly few data on CYP450 enzyme polymorphisms in indigenous American populations, and it is difficult to draw any clear inferences about how these populations might be expected to respond to drugs in relation to other racial or ethnic groups. This lack of information could create a barrier to the use of pharmacogenetic testing in these populations. Collaborative partnerships between indigenous communities and researchers are needed to avail the clinical benefits of CYP450 enzyme polymorphism testing to indigenous populations. Copyright (C) 2008 S. Karger AG, Basel.