The silent risks of blood transfusion
The silent risks of blood transfusion
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DOI：
10.1097/aco.0b013e32830f1fd1
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发表时间：
2008-10-01
影响因子：
2.5
通讯作者：
Rawn, James
中科院分区：
文献类型：
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作者：
Rawn, James
临床研究已经确定输血是近期和长期不良后果的独立危险因素，包括死亡、心肌梗死、中风、肾功能衰竭、感染和恶性肿瘤的风险增加。新的研究结果对临床医生在评估输血风险和益处时使用的传统假设提出了质疑。认识到新发现的风险对于保护稀缺资源和优化患者预后非常重要。最近的发现最近的临床结果研究检查了输血对危重病人、创伤病人、接受心脏手术的病人、急性冠状动脉综合征病人、肿瘤病人和其他病人的影响。这些研究提供了在各种临床情况下与输血相关的不良后果的额外证据。输血的益处从未得到确凿的证明，但输血相关危害的证据不断积累。鉴于目前在临床实践中占主导地位的输血触发因素，随着限制性输血策略的更广泛采用，临床结果似乎可以显著改善。
Purpose of reviewClinical research has identified blood transfusion as an independent risk factor for immediate and long-term adverse outcomes, including an increased risk of death, myocardial infarction, stroke, renal failure, infection and malignancy. New findings have called into question the traditional assumptions clinicians utilize in evaluating the risks and benefits of blood transfusion. Appreciation of newly recognized risks is important for conserving scarce resources and optimizing patient outcomes.Recent findingsRecent clinical outcomes research has examined the impact of blood transfusion on critically ill patients, trauma patients, patients undergoing cardiac surgery, patients experiencing acute coronary syndromes, oncology patients and others. These studies provide additional evidence of adverse outcomes associated with blood transfusion in a wide variety of clinical contexts.SummaryThe benefits of blood transfusion have never been conclusively demonstrated, but evidence of transfusion-related harm continues to accumulate. Given the transfusion triggers that currently predominate in clinical practice it appears that clinical outcomes could improve significantly with more widespread adoption of restrictive transfusion strategies.