Meibomian gland dysfunction in geriatric population: tehran geriatric eye study
Meibomian gland dysfunction in geriatric population: tehran geriatric eye study
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DOI：
10.1007/s10792-021-01812-2
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发表时间：
2021-03-24
影响因子：
1.6
通讯作者：
Khabazkhoob, Mehdi
中科院分区：
文献类型：
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作者：
Hashemi, Hassan;Asharlous, Amir;Khabazkhoob, Mehdi
目的确定伊朗老年人群中睑板腺功能障碍（MGD）的患病率及其危险因素。方法这项横断面研究于2019年进行。目标人群为居住在德黑兰的60岁及以上受试者。从所有德黑兰区进行多阶段整群抽样。在初次访谈后，所有受试者都接受了完整的眼科检查，包括视力和屈光度的测量以及裂隙灯生物显微镜检查，以评估睑板腺。结果在3791名被试中，有3310人参加了研究。对3284名参与者的数据进行了分析。受试者的平均年龄为68.24 ± 6.53岁（范围：60-97岁），其中57.8%为女性。MGD的总患病率为71.2%（68.3-74.1），分别有38.1%（8.35-40.4）、30.3%（27.4-33.2）和2.8%（2-3.6）的受试者患有MGD 2、3和4期。男性中MGD的患病率显著较高（p < 0.001），并且随着年龄的增长而增加，从60-64岁年龄组的64.4%增加到80岁及以上受试者的82.4%。吸烟者和非吸烟者之间MGD的患病率无显著差异;然而，重度MGD在吸烟者中更常见。在有和无眼部手术史的受试者中，MGD的患病率分别为76.3%和68.52%。有眼部手术史的受试者中MGD 3期和4期的患病率较高。结论与亚洲国家其他研究结果一致，本研究发现伊朗老年人群中MGD的患病率较高。发现男性、高龄是MGD的危险因素，吸烟、眼部手术史可加重MGD的病情。
Purpose To determine the prevalence of Meibomian gland dysfunction (MGD) and its risk factors in an elderly Iranian population Methods This cross-sectional study was conducted in 2019. The target population was the subjects aged 60 and over living in Tehran. Multistage cluster sampling was done to select the subjects from all Tehran districts. After an initial interview, all subjects underwent complete ophthalmic examinations including the measurement of visual acuity and refraction as well as slit lamp biomicroscopy to evaluate Meibomian glands. Results Of 3791 selected subjects, 3310 participated in the study. The data of 3284 participants were analyzed. The mean age of the subjects was 68.24 +/- 6.53 years (range: 60-97 years) and 57.8% of them were female. The total prevalence of MGD was 71.2% (68.3-74.1), and 38.1% (8.35-40.4), 30.3% (27.4-33.2), and 2.8% (2-3.6) of the subjects had MGD stage 2, 3, and 4, respectively. The prevalence of MGD was significantly higher in men (p < 0.001) and increased with age from 64.4% in the age group 60-64 years to 82.4% in subjects aged 80 years and over. There was no significant difference in the prevalence of MGD between smokers and nonsmokers; however, severe MGD was more common in smokers. The prevalence of MGD was 76.3% and 68.52% in subjects with and without a history of ocular surgery, respectively. The prevalence of MGD stage 3 and 4 was higher in subjects with a history of ocular surgery. Conclusions In line with the results of other studies in Asian countries, this study found a high prevalence of MGD in an elderly population of Iran. It was found that male gender and advanced age were risk factors of MGD and smoking and history of ocular surgery might worsen this disease in MGD patients.