Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy
Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy
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DOI：
10.1016/j.ijom.2012.01.017
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发表时间：
2012-08-01
影响因子：
2.4
通讯作者：
Rabenhorst, S. H. B.
中科院分区：
文献类型：
--
作者：
Nogueira, R. L. M.;Faria, M. H. G.;Rabenhorst, S. H. B.
中央巨细胞病变是一种罕见的颌骨良性病变，病因不明，临床表现多变。分子标记物的研究可能有助于了解这种病变的性质和行为，并最终可能成为药物治疗的靶点。本研究的目的是分析糖皮质激素和降钙素受体在中央巨细胞病变治疗前后的表达。石蜡包埋块从谁接受了治疗与病灶内注射曲安奈德治疗的患者进行染色化学染色。对治疗后接受外科手术的患者的生物材料进行化学检测。纳入18例（9例侵袭性和9例非侵袭性）。侵袭性和非侵袭性病变之间以及对治疗有良好反应的患者和对治疗有中度/阴性反应的患者之间降钙素受体表达的差异无统计学显著性。反应良好的患者多核巨细胞中糖皮质激素受体表达更高。可以推测，糖皮质激素受体的免疫组化染色可能提供了一种选择治疗策略的工具。在本研究中，多核巨细胞中糖皮质激素受体的H评分大于48预示着良好的反应。
Central giant cell lesion is an uncommon benign jaw lesion, with uncertain aetiology, and variable clinical behaviour. Studies of molecular markers may help to understand the nature and behaviour of this lesion, and eventually may represent a target for pharmacological approaches to treatment. The aim of this study was to analyse the expression of glucocorticoid and calcitonin receptors in central giant cell lesions before and after treatment with intralesional steroid. Paraffin-embedded blocks from patients who underwent treatment with intralesional triamcinolone hexacetonide injections were stained immunohistochemically. Biological material from patients who underwent a surgical procedure after treatment were tested immunohistochemically. 18 cases (9 aggressive and 9 non-aggressive) were included. The difference in calcitonin receptor expression was not statistically significant between the aggressive and non-aggressive lesions and between the patients with a good response and those with a moderate/negative response to treatment. Glucocorticoid receptor expression in the multinucleated giant cells was higher in patients with a good response. It can be postulated that immunohistochemical staining for glucocorticoid receptors may provide a tool for selecting the therapeutic strategy. An H-score greater than 48 for glucocorticoid receptors in multinucleated giant cells predicted a good response in this study.