Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review.
Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review.
复制标题
DOI：
10.1136/bjsports-2015-095100
复制
发表时间：
2015-12
影响因子：
18.4
通讯作者：
Gaida JE
中科院分区：
文献类型：
--
作者：
Tilley BJ;Cook JL;Docking SI;Gaida JE
肌腱疼痛发生在极端胆固醇水平的个体(家族性高胆固醇血症)。目前尚不清楚肌腱疼痛是否与胆固醇升高不那么极端有关。以确定血脂水平是否与肌腱结构异常或肌腱疼痛有关。我们进行了系统的综述和荟萃分析。计算机检索6个医学数据库--MEDLINE、Cochrane、Amed、EMBASE、Web of Science和Scope us，检索相关文章。我们纳入了所有病例对照或横断面研究，数据描述(1)血脂水平或降脂药物的使用，(2)肌腱结构或肌腱疼痛。17项研究(2612名参与者)符合纳入审查的条件。肌腱结构改变或肌腱疼痛的患者总胆固醇、低密度脂蛋白胆固醇、甘油三酯明显升高，高密度脂蛋白胆固醇明显降低，平均差值分别为0.66、1.00、0.33和−0.19 mm ol/L。这项综述的结果表明，个体的脂质状况和肌腱健康之间存在着关系。然而，还需要进一步的纵向研究来确定肌腱结构和血脂水平之间是否存在因果关系。这可能导致对肌腱病的病因学和治疗的理解的进步。
Tendon pain occurs in individuals with extreme cholesterol levels (familial hypercholesterolaemia). It is unclear whether the association with tendon pain is strong with less extreme elevations of cholesterol. To determine whether lipid levels are associated with abnormal tendon structure or the presence of tendon pain. We conducted a systematic review and meta-analysis. Relevant articles were found through an electronic search of 6 medical databases—MEDLINE, Cochrane, AMED, EMBASE, Web of Science and Scopus. We included all case–control or cross-sectional studies with data describing (1) lipid levels or use of lipid-lowering drugs and (2) tendon structure or tendon pain. 17 studies (2612 participants) were eligible for inclusion in the review. People with altered tendon structure or tendon pain had significantly higher total cholesterol, low-density lipoprotein cholesterol and triglycerides, as well as lower high-density lipoprotein cholesterol; with mean difference values of 0.66, 1.00, 0.33, and −0.19 mmol/L, respectively. The results of this review indicate that a relationship exists between an individual’s lipid profile and tendon health. However, further longitudinal studies are required to determine whether a cause and effect relationship exists between tendon structure and lipid levels. This could lead to advancement in the understanding of the pathoaetiology and thus treatment of tendinopathy.