Taurine in morning spot urine for the useful assessment of dietary seafood intake in Japanese children and adolescents.
Taurine in morning spot urine for the useful assessment of dietary seafood intake in Japanese children and adolescents.
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DOI：
10.1186/1423-0127-17-s1-s43
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发表时间：
2010-08-24
影响因子：
11
通讯作者：
Yamori Y
中科院分区：
文献类型：
--
作者：
Mori M;Mori H;Hamada A;Yamori Y
由于我们之前关于WHO心脏研究数据的报告表明，24小时尿(24U)牛磺酸(Tau)排泄是海鲜(SF)摄入量的有用生物标志物，并与世界上中风和冠心病的死亡率呈负相关，因此我们确定SF在降低与生活方式相关的疾病的风险方面非常重要。到目前为止，膳食中SF的摄入量是通过营养调查或24U Tau排泄量来估计的。据报道，尿钠/钾比值(SU)与24U/尿比值显著相关。因此，为了简化人群比较和跟踪食物教育过程中SF摄入量的变化，我们目前研究了清晨SU和24U Tau之间的关系。经知情同意后，54名6~11岁儿童(儿童组)和193名13~18岁青少年(青少年组)在当天准确采集首次尿液24U和SU，并回答调查问卷，包括年龄、身高和体重测量。测定尿中肌酐(Cre)和牛磺酸(Tau)，并分析24U与SU的相关性。儿童和青少年24U采样成功率很高，分别为96.4%和82.4%。对儿童和青少年24U牛磺酸排泄量的预测公式为：儿童：24U牛磺酸=16.3U(体重)+314.3(苏牛头/肌酐)-175.2；青少年：24U牛磺酸=20.2%(体重)+644.7(苏头/肌酐)-569.4。本研究建立了由SU-Tau/Cre和体重估算24U-Tau排泄量的回归方程。这些公式有望有助于估计鱼和SF的摄入量，并跟踪FEP对儿童和青少年饮食行为的改变。
Since our previous report on WHO CARDIAC Study data demonstrated that 24-hour urinary (24U) taurine (Tau) excretion was a useful biomarker of seafood (SF) intake and inversely related to the mortality rates of stroke and coronary heart diseases in the world, we determined that SF is important in the risk reduction of lifestyle related-diseases. The amounts of dietary SF intake are so far estimated from a nutritional survey or 24U Tau excretion. The sodium/potassium ratio of spot urine (SU) and the 24U ratio were reported to be significantly correlated with. Therefore, we presently examined the relationship of Tau excretion in the morning SU with 24U Tau for simplifying the population comparison and the follow-up of SF intake changes in the process of food education program (FEP). After informed consent was obtained, 54 children aged 6-11 years (Children) and 193 adolescents aged 13-18 years (Adolescents) participated in collecting precisely 24U and SU of the first urination on the same day and answered the questionnaire including age and height and weight measurements. The urine samples were measured for creatinine (Cre) and Tau, and the association of these between 24U and SU were analyzed. The success rates of 24U sampling were very high in Children and Adolescents, 96.4% and 82.4%, respectively. From the result of the multiple regression analysis of SU Tau/Cre and weight we obtained formulas for predicting 24U Tau excretion in Children and Adolescents as follows: Children: 24U Tau = 16.3 (weight) + 314.3 (SU Tau/Cre) -175.2; and Adolescents: 24U Tau = 20.2 (weight) + 644.7 (SU Tau/Cre) - 569.4. The present study established the regression equation to estimate 24U Tau excretion from SU Tau/Cre and weight. These formulas are expected to contribute to the estimation of fish and SF intake and the follow-up of the change of the dietary behavior by FEP in Children and Adolescents.