Sensorimotor and Frontoparietal Network Connectivity Are Associated With Subsequent Maintenance of Gait Speed and Episodic Memory in Older Adults.
Sensorimotor and Frontoparietal Network Connectivity Are Associated With Subsequent Maintenance of Gait Speed and Episodic Memory in Older Adults.
复制标题
感觉运动和额顶叶网络连接与老年人步态速度和情景记忆的后续维持有关。
DOI：
10.1093/gerona/glac193
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Lipsitz,LewisA
中科院分区：
文献类型：
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作者：
Hsu,ChunLiang;Manor,Brad;Travison,Thomas;Pascual-Leone,Alvaro;Lipsitz,LewisA
背景步态缓慢是老年人功能障碍的预测指标，而伴随的步态缓慢和认知功能障碍与认知功能下降和痴呆的风险更大有关。然而，步态速度维持的功能神经相关性尚不清楚。由于感觉运动网络（SMN）和额顶叶网络（FPN）是这些功能的组成部分，本研究探讨了在SMN和FPN的差异，在老年人与/无步态速度下降超过24个月，以及这些网络是否与维护认知functions.MethodsWe包括42个社区居住的老年人年龄>70岁的MOBILIZE波士顿研究。在研究基线时进行静息状态fMRI。在基线和24个月随访时评估参与者特征、步态速度、简易精神状态检查和霍普金斯言语学习测试（HVLT）。下降者被确定为从基线到24个月步态速度下降>0.05米/秒的个体。在26名下降者和16名维持者中，下降者在HVLT上的延迟回忆表现在24个月内显著下降。结果控制基线年龄和多重比较，与最初的假设相反，维持者表现出较低的基线初级运动和运动前区连接（p= 0.01），FPN（p= 0.02）内的基线腹侧视觉-缘上回连接性高于下降者。较低的初级电机运动前连接与维持延迟回忆性能的HVLT（p= .04）。ConclusionThese研究结果表明，潜在的补偿机制参与之间的联系，在步态速度和情节记忆的下降，从而基线连接的SMN和FPN可能是随后的维护步态速度和认知功能在老年。
BackgroundSlow gait is predictive of functional impairments in older adults, while concomitant slow gait and cognitive complaints are associated with a greater risk for cognitive decline and dementia. However, functional neural correlates for gait speed maintenance are unclear. As the sensorimotor network (SMN) and frontoparietal network (FPN) are integral components of these functions, this study investigated differences in SMN and FPN in older adults with/without gait speed decline over 24 months; and whether these networks were associated with the maintenance of cognitive function.MethodsWe included 42 community-dwelling older adults aged >70 years from the MOBILIZE Boston Study. Resting-state fMRI was performed at the study baseline. Participant characteristics, gait speed, Mini-Mental State Examination, and Hopkins Verbal Learning Test (HVLT) were assessed at baseline and at 24-month follow-up. Decliners were identified as individuals with >0.05 meters/second decline in gait speed from baseline to 24 months. Of the 26 decliners and 16 maintainers, decliners exhibited a significant decline in delayed-recall performance on the HVLT over 24 months.ResultsControlling for baseline age and multiple comparisons, contrary to initial hypothesis, maintainers exhibited lower baseline primary motor and premotor connectivity (p= .01) within the SMN, and greater baseline ventral visual–supramarginal gyrus connectivity within the FPN (p= .02) compared to decliners. Lower primary motor–premotor connectivity was correlated with maintenance of delayed-recall performance on the HVLT (p= .04).ConclusionThese findings demonstrated a potential compensatory mechanism involved in the link between the decline in gait speed and episodic memory, whereby baseline connectivity of the SMN and FPN may underlie subsequent maintenance of gait speed and cognitive function in old age.