Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women
Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women
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DOI：
10.1016/j.ijheh.2010.10.001
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发表时间：
2011-03-01
影响因子：
6
通讯作者：
Rabah, Abdullah
中科院分区：
文献类型：
--
作者：
Al-Saleh, Iman;Shinwari, Neptune;Rabah, Abdullah
对2005年至2006年间在Al-Kharj King Khalid医院分娩的1578名妇女的胎盘组织、脐带和孕产妇血液样本中的铅、镉和汞进行了测量。本研究的目的是评估母亲和新生儿的重金属暴露状况，并确定母亲暴露的预测因素。在所有的脐带血和母血以及96%的胎盘组织中都检测到了铅。仅在0.89%和0.83%的脐带血和母体血样本中铅水平高于CDC阈值限值10 μ g/dl。孕妇血铅也高于德国妇女参考值7 μ g/dl（2.3%）。大约9.3%的妇女胎盘铅含量高于第95百分位数，范围为0.83-78 μ g/g干重，可能的发育毒性在94.8%和97.9%的脐带血和母亲血液样本中分别检测到镉，尽管只有5名新生儿的镉水平高于OSHA的阈值限值5 μ g/l。将我们的结果与新修订的德国非吸烟者参考值进行比较，48.6%的母亲血镉水平>1.0 μ g/l。我们还发现，25%的妇女胎盘镉含量在> 75%，范围为0.048-4.36 μ g/g干重，这可能会影响胎儿的生长和发育。在母亲和脐带血样本中，分别有11.2%和13%的汞含量>5.8 μ g/l，这是EPA的参考剂量。近49%的妇女汞含量>2.0 μ g/l，这是德国食用鱼类的参考值
Lead, cadmium and mercury were measured in placental tissue, umbilical cord and maternal blood samples of 1578 women who delivered at the Al-Kharj King Khalid Hospital between 2005 and 2006. The aim of this study was to evaluate the status of heavy metal exposure in mothers and their newborns and to identify predictors of maternal exposure. Lead was detected in all cord and maternal blood and in 96% of placental tissues. Only in 0.89% and 0.83% of cord and maternal blood samples were the levels of lead above the CDC threshold limit of 10 mu g/dl. Maternal blood lead was also higher (2.3%) than the German Reference value in women of 7 mu g/dl. Approximately 9.3% of women had a placental lead above the 95th percentile in the range of 0.83-78 mu g/g dry wt., a level of possible developmental toxicity. Cadmium was detected in 94.8% and 97.9% of cord and maternal blood samples respectively, though only five newborns had a cadmium level above the OSHA threshold limit of 5 mu g/l. Comparing our results to the newly revised German Reference value for nonsmokers, 48.6% of mothers had blood cadmium levels >1.0 mu g/l. We found as well that 25% of women had placental cadmium in the >75th percentile, in the range of 0.048-4.36 mu g/g dry wt., which is likely to affect fetal growth and development. Of the maternal and cord blood samples, 11.2% and 13%, respectively, had mercury levels >5.8 mu g/l, which is the EPA reference dose. Nearly 49% of women had mercury levels >2.0 mu g/l, the German Reference value for those who consume fish