Neither too much nor too little: reactive oxygen species levels regulate Drosophila hematopoiesis.
Neither too much nor too little: reactive oxygen species levels regulate Drosophila hematopoiesis.
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DOI：
10.1093/jmcb/mjp042
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发表时间：
2010-04
影响因子：
5.5
通讯作者：
A. Vincent;M. Crozatier
中科院分区：
文献类型：
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作者：
A. Vincent;M. Crozatier
由于它们的快速扩散，活性氧（ROS）是重要的组织信号传导组分。高水平的ROS通常被认为对细胞有害。果蝇造血器官的体内实验现在挑战了这一观点，表明高活性氧水平是骨髓样祖细胞分化的内在要求。
Owing to their fast diffusion, reactive oxygen species (ROS) are important tissue signalling components. High levels of ROS are generally considered as deleterious to cells. In vivo experiments in the Drosophila hematopoietic organ now challenge this view by showing that high ROS levels are intrinsically required to prime myeloid-like progenitors to differentiate.