Neural and behavioural responses to face-likeness of objects in adolescents with autism spectrum disorder.
Neural and behavioural responses to face-likeness of objects in adolescents with autism spectrum disorder.
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DOI：
10.1038/srep03874
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发表时间：
2014-01-27
影响因子：
4.6
通讯作者：
Hasegawa T
中科院分区：
文献类型：
--
作者：
Akechi H;Kikuchi Y;Tojo Y;Osanai H;Hasegawa T
许多研究表明，自闭症谱系障碍（ASD）的特征是社会互动和沟通困难的非典型面孔加工。本研究调查了ASD患者对面部相似性的敏感性。在实验1中，我们发现ASD（11-19岁）和典型发展（TD）组（9-21岁）的非面部物体的面部相似性评级之间存在很强的正相关。在实验2（头皮记录的事件相关电位实验）中，两组（ASD，12-19岁; TD，12-18岁）的参与者表现出增强的面部敏感N170振幅的脸一样的物体。而TD青少年表现出增强的N170在面孔相似性的判断，青少年与ASD没有。因此，患有ASD和TD的个体都对物体中的面部特征具有感知和神经敏感性。当需要处理类似面部的特征时，与面部相关的大脑系统在TD个体中反应更强烈，但在ASD个体中则不然。
Numerous studies have revealed atypical face processing in autism spectrum disorders (ASD) characterized by social interaction and communication difficulties. This study investigated sensitivity to face-likeness in ASD. In Experiment 1, we found a strong positive correlation between the face-likeness ratings of non-face objects in the ASD (11–19 years old) and the typically developing (TD) group (9–21 years old). In Experiment 2 (the scalp-recorded event-related potential experiment), the participants of both groups (ASD, 12–19 years old; TD, 12–18 years old) exhibited an enhanced face-sensitive N170 amplitude to a face-like object. Whereas the TD adolescents showed an enhanced N170 during the face-likeness judgements, adolescents with ASD did not. Thus, both individuals with ASD and TD individuals have a perceptual and neural sensitivity to face-like features in objects. When required to process face-like features, a face-related brain system reacts more strongly in TD individuals but not in individuals with ASD.