Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients
Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients
复制标题
低血清阿降蛋白与 2 型糖尿病和非糖尿病患者的冠状动脉粥样硬化有关
DOI：
10.1515/cclm-2013-0844
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发表时间：
2014-05-01
影响因子：
6.8
通讯作者：
Fan, Lin
中科院分区：
文献类型：
--
作者：
Wu, Lingzhen;Fang, Jun;Fan, Lin
摘要背景：糖尿病增加动脉粥样硬化的风险和严重程度。Adropin是一种代谢稳态相关蛋白，参与维持代谢稳态。我们研究了糖尿病和非糖尿病患者血清肾上腺素水平与冠状动脉粥样硬化程度的关系。研究方法：将392例疑有冠心病并行冠状动脉造影的患者分为2型糖尿病组和非糖尿病组，并根据肾上腺素水平的四分位数将其分为4组。采集静脉血清标本，用酶联免疫吸附法测定Adropin，并进行生化检测。通过Gensini、Friesinger和SYNTAX评分评估冠状动脉粥样硬化的血管造影严重程度。结果如下：与非糖尿病患者相比，糖尿病患者血清Adropin水平较低，Gensini、Friesinger和SYNTAX评分较高（均P<0.001）。所有患者的血清Adropin水平与Gensini、Friesinger和SYNTAX评分呈负相关（rs分别为-0.389、-0.390和-0.386，p均<0.001）。低肾上腺素水平是临床相关冠状动脉粥样硬化（SYNTAX评分>11）的独立预测因子，在糖尿病患者[比值比（OR）0.66，95%置信区间（CI）0.53-0.83; p<0.001]和非糖尿病患者中均是如此（OR 0.51，95% CI 0.35-0.74; p<0.001）。结论：2型糖尿病患者血清肾上腺素水平显著低于非糖尿病患者，且与冠状动脉粥样硬化程度呈独立负相关，提示血清肾上腺素可作为冠状动脉粥样硬化的一种新的预测因子。
Abstract Background: Diabetes increases the risk and severity of atherosclerosis. Adropin, a metabolic homeostasis-related protein, has been implicated in the maintenance of metabolic homeostasis. We examined the relationship between serum adropin level and angiographic severity of coronary atherosclerosis in diabetic and non-diabetic patients. Methods: A total of 392 patients with suspected coronary artery disease, who underwent coronary angiography, were assigned into the type 2 diabetic and non-diabetic groups and also classified into four groups according to the quartiles of adropin level. Venous serum samples were collected for adropin measurement by enzyme-linked immunosorbent assay and for biochemistry assay. The angiographic severity of coronary atherosclerosis was assessed by Gensini, Friesinger, and SYNTAX scores. Results: Compared with non-diabetic patients, diabetic patients had lower serum adropin level and higher Gensini, Friesinger and SYNTAX scores (all p<0.001). Serum adropin level was inversely correlated with the Gensini, Friesinger and SYNTAX scores (rs=–0.389, –0.390 and –0.386, respectively, all p<0.001) among all patients. Low adropin level was an independent predictor of clinically relevant coronary atherosclerosis (SYNTAX score >11), both in diabetic patients [odds ratio (OR) 0.66, 95% confidence interval (CI) 0.53–0.83; p<0.001] and in non-diabetic patients (OR 0.51, 95% CI 0.35–0.74; p<0.001). Conclusions: Serum adropin level was significantly lower in type 2 diabetic patients than in non-diabetic patients and was inversely and independently associated with angiographic severity of coronary atherosclerosis, suggesting that serum adropin serves as a novel predictor of coronary atherosclerosis.