TRANS-ACTING DOSAGE EFFECTS ON THE EXPRESSION OF MODEL GENE SYSTEMS IN MAIZE ANEUPLOIDS
TRANS-ACTING DOSAGE EFFECTS ON THE EXPRESSION OF MODEL GENE SYSTEMS IN MAIZE ANEUPLOIDS
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DOI：
10.1126/science.266.5193.1999
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发表时间：
1994-12-23
期刊：
影响因子：
56.9
通讯作者：
BIRCHLER, JA
中科院分区：
文献类型：
--
作者：
GUO, M;BIRCHLER, JA
非整倍体活力的降低被经典地认为是由于从变异染色体表达的基因产物相对于从基因组的其余部分表达的基因产物的不平衡。在这项研究中，染色体片段的剂量是不同的，但其中编码的大多数基因的转录水平显示出对基因拷贝数的补偿。剂量未改变的基因受到非连锁染色体片段非整倍性的影响。非整倍体和大量数量变异的表型效应被假设为是剂量敏感性调节系统改变的结果。
The reduction in vigor of aneuploids was classically thought to be due to the imbalance of gene products expressed from the varied chromosome relative to those from the remainder of the genome. In this study, the dosage of chromosomal segments was varied, but the transcript level of most genes encoded therein showed compensation for the number of copies of the gene. Genes whose dosage was not altered were affected by aneuploidy of unlinked chromosomal segments. The phenotypic effects of aneuploidy and of a substantial fraction of quantitative variation are hypothesized to be the consequence of an altered dosage-sensitive regulatory system.