Creating a graft-friendly environment for stem cells in diseased brains.
Creating a graft-friendly environment for stem cells in diseased brains.
复制标题
DOI：
10.1172/jci98490
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
R. Y. Tsai
中科院分区：
文献类型：
--
作者：
R. Y. Tsai
大多数成年中枢神经系统在神经元生成和神经突生长方面缺乏再生活性。虽然成人中枢神经系统的这种不友好的再生环境可能保留了高等生物体中需要数年才能发育的现有神经回路，但它也对中枢神经系统在以后的生命中修复构成了主要障碍。在这一期的JCI中，Song等人报道了他们开发的一种策略，该策略使用区域特异性和分子工程星形胶质细胞将不利的大脑环境转变为有利于移植神经干/祖细胞（NSC/ npc）的环境。在帕金森病（PD）大鼠模型中，将npc与中脑来源的星形胶质细胞共移植，使其过度表达转录因子Nurr1和Foxa2，可促进移植物的成熟和存活，从而改善治疗效果。本研究的结果提出了使用修饰的星形胶质细胞来改善移植的NSC/NPCs的存活、成熟和整合作为PD恢复性治疗的前景。
Most of the adult CNS lacks regenerative activity in terms of both neuron birth and neurite outgrowth. While this regeneration-unfriendly environment of the adult CNS may preserve the existing neuronal circuitry that takes years to develop in higher organisms, it also poses a major obstacle for CNS repair later in life. In this issue of the JCI, Song et al. report on their development of a strategy that uses region-specific and molecularly engineered astrocytes to turn an unfavorable brain environment into a favorable one for engrafted neural stem/progenitor cells (NSC/NPCs). In a rat model of Parkinson's disease (PD), cografting NPCs with midbrain-derived astrocytes engineered to overexpress the transcription factors Nurr1 and Foxa2 promotes maturation and survival of the graft, resulting in therapeutic improvement. The results of this study raise the prospect of using modified astrocytes to improve the survival, maturation, and integration of engrafted NSC/NPCs as a restorative treatment for PD.