EARLY CHANGES IN EXPERIMENTAL HYDROCEPHALUS
EARLY CHANGES IN EXPERIMENTAL HYDROCEPHALUS
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DOI：
10.1097/00004424-198602000-00006
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发表时间：
1986-02-01
影响因子：
6.7
通讯作者：
JAMES, AE
中科院分区：
文献类型：
--
作者：
DIGGS, J;PRICE, AC;JAMES, AE
在脑脊液（CSF）吸收途径的急性阻塞中，液体的产生比吸收更快，并且脑室在阻塞物近端扩大。交通性脑积水是由于脑脊液的产生和吸收速率不同而引起的。在慢性交通性脑积水动物中，最初的病理变化似乎涉及侧脑室角附近的脑室周围组织。本研究旨在确定与急性脑积水制剂中交通性脑积水的产生相关的各种变化，并将这些结果与慢性交通性脑积水实验动物中发现的结果联系起来。本研究的结果似乎证实，在慢性脑积水动物中观察到的变化早在CSF正常流动受限后12小时就发生了。
In acute obstruction of the cerebral spinal fluid (CSF) absorption pathways, fluid is produced more rapidly than it is absorbed, and the ventricles enlarge proximal to the obstructions. Communicating hydrocephalus results from a difference between the rates of production and absorption of cerebrospinal fluid. In animals with chronic communicating hydrocephalus, the initial pathologic changes appear to involve the periventricular tissue near the angles of the lateral ventricles. The present investigation was designed to identify the various changes associated with the production of communicating hydrocephalus in acutely hydrocephalic preparations and to relate these findings to those found in experimental animals with chronic communicating hydrocephalus. The results of this study seem to confirm that the changes noted in the chronically hydrocephalic animals occur as early as 12 hours after the restriction of the normal flow of CSF.