Dissecting the components of long-term potentiation.
Dissecting the components of long-term potentiation.
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DOI：
10.1177/1073858408320643
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Zakharenko SS
中科院分区：
文献类型：
--
作者：
Blundon JA;Zakharenko SS
记忆的形成依赖于神经元之间突触的可塑性变化。尽管几十年来突触可塑性的机制已经被广泛研究，但这一过程的许多方面仍然存在争议。作为突触可塑性的一种主要形式，长时程增强(LTP)的细胞表达位点是最重要的未解现象之一。在这篇文章中，我们总结了新的成像工具的发展使这一领域的一些最新进展成为可能。这些研究表明，LTP本质上是复合体，由突触前成分和突触后成分组成。我们还回顾了复合LTP过程中突触前和突触后变化的一些特征。
The formation of memories relies on plastic changes at synapses between neurons. Although the mechanisms of synaptic plasticity have been studied extensively over several decades, many aspects of this process remain controversial. The cellular locus of expression of long-term potentiation (LTP), a major form of synaptic plasticity, is one of the most important unresolved phenomena. In this article, we summarize some recent advances in this area made possible by the development of new imaging tools. These studies have demonstrated that LTP is compound in nature and consists of both presynaptic and postsynaptic components. We also review some features of presynaptic and postsynaptic changes during compound LTP.