ANTAGONISM OF ESTROGEN-INDUCED LORDOSIS BY CORTICOSTERONE IN ADRENALECTOMIZED-OVARIECTOMIZED FEMALE RATS AND MICE
ANTAGONISM OF ESTROGEN-INDUCED LORDOSIS BY CORTICOSTERONE IN ADRENALECTOMIZED-OVARIECTOMIZED FEMALE RATS AND MICE
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DOI：
10.1016/0091-3057(81)90019-8
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发表时间：
1981-01-01
影响因子：
3.6
通讯作者：
GORZALKA, BB
中科院分区：
文献类型：
--
作者：
DECATANZARO, D;KNIPPING, RP;GORZALKA, BB
先前的实验证实，肾上腺切除术可以促进卵巢切除、雌激素引发的雌性大鼠的脊柱前凸。实验1检查了肾上腺类固醇在这种作用中的作用，结果表明慢性皮质酮会减弱，但脱氧皮质酮或黄体酮给药不会减弱。建立了皮质酮效应的剂量反应曲线。在雌激素给药之前给予皮质酮可抑制脊柱前凸。皮质酮还可以抑制雌激素引起的小鼠脊柱前凸。皮质酮可以调节啮齿动物雌激素介导的行为。
Previous experimentation established that adrenalectomy can facilitate lordosis in ovariectomized estrogen-primed female rats. Experiment 1 examined the role of adrenal steroids in this effect, the results indicating an attenuation with chronic corticosterone but not with deoxycorticosterone or progesterone administration. A dose-response curve for this corticosterone effect was established. Corticosterone administration inhibits lordosis when it precedes estrogen administration. Corticosterone also inhibits estrogen-induced lordosis in mice. Corticosterone may modulate estrogen-mediated behavior in rodents.