Cruciferous vegetable intake and lung cancer risk: a nested case-control study matched on cigarette smoking.
Cruciferous vegetable intake and lung cancer risk: a nested case-control study matched on cigarette smoking.
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DOI：
10.1158/1055-9965.epi-10-0475
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Alberg AJ
中科院分区：
文献类型：
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作者：
Lam TK;Ruczinski I;Helzlsouer KJ;Shugart YY;Caulfield LE;Alberg AJ
由于吸烟，肺癌是世界范围内与癌症相关的主要死亡原因。十字花科蔬菜可以降低患肺癌的风险。CLUE II研究调查了十字花科蔬菜摄入量与肺癌风险之间的关系，该研究是1989年建立的一项社区队列研究。我们将1990-2005年间诊断出的274例肺癌病例与1089例无癌症对照进行了年龄、性别和吸烟情况的匹配。在基线时收集饮食信息。使用条件逻辑回归计算多变量优势比（ORs）和95%置信区间（ci）。摄入十字花科蔬菜与肺癌风险呈负相关（最高四分之一vs最低四分之一：OR Q4vsQ1=0）。57;95%ci = 0.38-0.85；p-trend = 0.01)。前吸烟者（ORQ4vsQ1=0.49; 95%CI = 0.27-0.92； p趋势=0.05）和当前吸烟者(ORQ4vsQ1)= 0.52；95%ci = 0.29-0.95；p-trend = 0.02)。在仔细控制吸烟后，摄入更多十字花科蔬菜与降低肺癌风险相关。观察到的负相关，加上越来越多的证据表明十字花科蔬菜与肺癌风险呈负相关，这种关联似乎超越了吸烟的混杂影响。
Due predominantly to cigarette smoking, lung cancer is the leading cancer-related cause of death worldwide. Cruciferous vegetables may reduce lung cancer risk. The association between intake of cruciferous vegetables and lung cancer risk was investigated in the CLUE II study, a community-based cohort established in 1989. We matched 274 incident cases of lung cancer diagnosed from 1990–2005 to 1089 cancer-free controls on age, sex, and cigarette smoking. Dietary information was collected at baseline. Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Intake of cruciferous vegetables were inversely associated with lung cancer risk (highest-versus-lowest fourth: OR Q4vsQ1=0. 57; 95%CI = 0.38–0.85; p-trend=0.01). The inverse associations held true for former smokers (ORQ4vsQ1=0.49; 95%CI = 0.27–0.92; p-trend=0.05) and current smokers (ORQ4vsQ1)= 0.52; 95%CI = 0.29–0.95; p-trend=0.02). After careful control of cigarette smoking, higher intake of cruciferous vegetable was associated with lower risk of lung cancer. The observed inversed association coupled with the accumulating evidence suggests that cruciferous vegetables are inversely associated lung cancer risk and this association seems to hold true beyond the confounding effects of cigarette smoking.