Late developmental changes in the ability of adenosine A1 receptors to regulate synaptic transmission in the hippocampus
Late developmental changes in the ability of adenosine A1 receptors to regulate synaptic transmission in the hippocampus
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DOI：
10.1016/s0165-3806(97)00152-1
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发表时间：
1998-01-14
期刊：
影响因子：
--
通讯作者：
Foster, TC
中科院分区：
文献类型：
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作者：
Dumas, TC;Foster, TC
比较了幼年大鼠（出生后15-21日）和成年大鼠（28- 35日）海马切片中CA3-CA1兴奋性突触后电位（EPSP）的成对脉冲促进（PPF）。相对于青少年，年轻的成虫表现出基线突触强度的增加，同时伴随着PPF的减少，这表明发育中递质释放的增加。虽然腺苷对青少年和青壮年EPSP斜率的抑制程度相似，但只有青壮年的PPF在腺苷的作用下增加。腺苷对PPF的不同影响不是由于受体功能或细胞外配体水平的差异，因为A拮抗剂环戊基茶碱（CPT）对PPF的影响在不同年龄之间没有差异。腺苷可以在增强递质释放的条件下，通过增加浴液Ca2+浓度或在浴液中添加福斯克林来增加幼鱼切片的PPF。这些数据表明，随着释放机制的成熟，通过突触前腺苷A受体改变突触传递的能力在出生后的发育过程中增加。(C) 1998爱思唯尔科学有限公司
Paired-pulse facilitation (PPF) of CA3-CA1 excitatory postsynaptic potentials (EPSP) was compared in hippocampal slices from juvenile (postnatal day (P) 15-21) and young adult rats (P28-P35) following application of adenosine. Relative to juveniles, young adults expressed an increase in baseline synaptic strength that was accompanied by a decrease in PPF suggesting a developmental increase in transmitter release. While adenosine depressed the EPSP slope to a similar extent in juveniles and young adults, PPF increased during adenosine application only for young adults. The differential effect of adenosine on PPF was not due to differences in receptor function or in extracellular ligand levels, since the A, antagonist cyclopentyltheophylline (CPT) did not differentially affect PPF across age. Adenosine could increase PPF in juvenile slices under conditions of enhanced transmitter release, through an increase in the bath Ca2+ concentration, or addition of forskolin to the bath. These data indicate that the ability to modify synaptic transmission through presynaptic adenosine A, receptors increases across postnatal development with the maturation of release mechanisms. (C) 1998 Elsevier Science B.V.