LIF and IL11 in trophoblast-endometrial interactions during the establishment of pregnancy
LIF and IL11 in trophoblast-endometrial interactions during the establishment of pregnancy
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DOI：
10.1016/j.placenta.2009.12.027
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发表时间：
2010-03-01
期刊：
影响因子：
3.8
通讯作者：
Paiva, P.
中科院分区：
文献类型：
--
作者：
Dimitriadis, E.;Menkhorst, E.;Paiva, P.
胚泡植入子宫内膜对于妊娠的建立至关重要，并且受到胚泡-子宫内膜微环境内的因素的严格调节。着床是一个连续的过程，包括胚泡粘附到子宫内膜上皮，然后滋养层穿透上皮。滋养层细胞增殖并侵入子宫内膜，其亚群可重塑螺旋动脉。人类滋养层-子宫内膜相互作用涉及对妊娠成功至关重要的因素的精心策划的时间和空间变化。新出现的证据表明，在植入的各个阶段，当地产生的细胞因子，包括白细胞介素11和白血病抑制因子的重要作用。本文综述了这些细胞因子在人类妊娠建立过程中滋养层-子宫内膜相互作用中的作用。(C)2010年由IFPA和Elsevier Ltd.出版
Blastocyst implantation into the endometrium is critical for the establishment of pregnancy and is tightly regulated by factors within the blastocyst-endometrial micro-environment. Implantation is a continuum involving blastocyst adhesion to the endometrial epithelium followed by trophoblast penetration of the epithelium. The trophoblast proliferates and invades through the endometrium, with a subpopulation acting to remodel the spiral arteries. Trophoblast-endometrial interactions in humans involve carefully orchestrated temporal and spatial alterations in factors that are critical for pregnancy success. Emerging evidence suggests important roles for locally produced cytokines including interleukin 11 and leukemia inhibitory factor in the various stages of implantation. This review focuses on the role of these cytokines in trophoblast-endometrial interactions during the establishment of human pregnancy. (C) 2010 Published by IFPA and Elsevier Ltd.