Neurocognitive effects of HF-rTMS over the dorsolateral prefrontal cortex on the attentional processing of emotional information in healthy women: An event-related fMRI study
Neurocognitive effects of HF-rTMS over the dorsolateral prefrontal cortex on the attentional processing of emotional information in healthy women: An event-related fMRI study
复制标题
DOI：
10.1016/j.biopsycho.2010.09.015
复制
发表时间：
2010-12-01
影响因子：
2.6
通讯作者：
Dannlowski, Udo
中科院分区：
文献类型：
--
作者：
De Raedt, Rudi;Leyman, Lemke;Dannlowski, Udo
目前关于注意力和情绪之间相互作用的神经回路的证据主要是相关的。我们使用高频重复经颅磁刺激 (HF-rTMS) 来实验性地操纵健康女性右或左背外侧前额皮质 (DLPFC) 内的活动，并在事件相关功能磁共振成像期间使用外源提示任务的情绪修改来检查情绪信息注意力处理的变化。右侧前额叶 HF-rTMS 导致对愤怒面孔的脱离能力受损，这与右侧 DLPFC、背侧前扣带皮层 (dACC) 和左侧顶上回的激活减少以及右侧杏仁核内的活动增加有关。左前额叶 HF-rTMS 导致愤怒面孔的注意力减少，并与右 DLPFC、dACC、右顶上回和左眶额皮层活动增加相关。目前的观察结果与皮质边缘通路功能交互网络的报告一致，该通路在情绪调节中发挥着核心作用。 (C) 2010 Elsevier B.V. 保留所有权利。
Current evidence concerning the neurocircuitry underlying the interplay between attention and emotion is mainly correlational. We used high-frequency repetitive Transcranial Magnetic Stimulation (HF-rTMS) to experimentally manipulate activity within the right or left dorsolateral prefrontal cortex (DLPFC) of healthy women and examined changes in attentional processing of emotional information using an emotional modification of the exogenous cueing task during event-related fMRI. Right prefrontal HF-rTMS resulted in impaired disengagement from angry faces, associated with decreased activation within the right DLPFC, dorsal anterior cingulate cortex (dACC) and left superior parietal gyrus, combined with increased activity within the right amygdala. Left prefrontal HF-rTMS resulted in diminished attentional engagement by angry faces and was associated with increased activity within the right DLPFC,dACC, right superior parietal gyrus and left orbitofrontal cortex. The present observations are in line with reports of a functionally interactive network of cortical-limbic pathways that play a central role in emotion regulation. (C) 2010 Elsevier B.V. All rights reserved.