GED: a manually curated comprehensive resource for epigenetic modification of gametogenesis
GED: a manually curated comprehensive resource for epigenetic modification of gametogenesis
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DOI：
10.1093/bib/bbw007
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发表时间：
2017-01-01
影响因子：
9.5
通讯作者：
Liao, Mingzhi
中科院分区：
文献类型：
--
作者：
Bai, Weiyang;Yang, Wen;Liao, Mingzhi
生殖不育影响了七分之一的夫妇，这主要归因于配子发生障碍。研究配子体发生过程中的表观遗传修饰因素是了解配子体发生的分子机制和开发人类不孕症治疗方法的基础。虽然遗传因素与配子发生有关，但没有专门的配子发生生物信息学资源。为了阐明表观遗传修饰与哺乳动物配子发生的关系，我们建立了一个新的数据库——gametogenesis epigenetic modification database (GED)，一个人工整理的数据库，旨在为配子发生的表观遗传修饰提供一个全面的资源。该数据库整合了配子发生过程中DNA甲基化、组蛋白修饰和RNA调控等3种表观遗传修饰信息，将7种哺乳动物（智人、小家鼠、褐家鼠、牛、牛、山羊和羊）的配子发生过程划分为16个阶段。此外，我们还预测了由211个参与配子体发生的基因/蛋白和microrna组成的表观遗传修饰的线性通路。GED是一个用户友好的网站，用户可以通过免费访问我们的数据库，获得全面的表观遗传因子信息和分子途径。GED免费下载网址：http://gametsepi.nwsuaflmz.com。
Reproductive infertility affects seventh of couples, which is most attributed to the obstacle of gametogenesis. Characterizing the epigenetic modification factors involved in gametogenesis is fundamental to understand the molecular mechanisms and to develop treatments for human infertility. Although the genetic factors have been implicated in gametogenesis, no dedicated bioinformatics resource for gametogenesis is available. To elucidate the relationship of epigenetic modification and mammalian gametogenesis, we developed a new database, gametogenesis epigenetic modification database (GED), a manually curated database, which aims at providing a comprehensive resource of epigenetic modification of gametogenesis. The database integrates three kinds information of epigenetic modifications during gametogenesis (DNA methylation, histone modification and RNA regulation), and the gametogenesis has been detailed as 16 stages in seven mammal species (Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Bos taurus, Capra hircus and Ovis aries). Besides, we have predicted the linear pathways of epigenetic modification which were composed of 211 genes/proteins and microRNAs that were involved in gametogenesis. GED is a userfriendly Web site, through which users can obtain the comprehensive epigenetic factor information and molecular pathways by visiting our database freely. GED is free available at http://gametsepi.nwsuaflmz.com.