RNAs from genetically distinct retroviruses can copackage and exchange genetic information in vivo.
RNAs from genetically distinct retroviruses can copackage and exchange genetic information in vivo.
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来自遗传上不同的逆转录病毒的RNA可以在体内共同包装和交换遗传信息。
DOI：
10.1128/jvi.71.8.6237-6242.1997
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发表时间：
1997
影响因子：
5.4
通讯作者：
Hu,WS
中科院分区：
文献类型：
--
作者：
Yin,PD;Hu,WS
序列分析表明，古老的重组事件可能发生在基因不同的逆转录病毒之间。利用实验系统探索不同病毒之间的遗传相互作用。Moloney鼠肉瘤病毒和脾坏死病毒是属于不同亚属的C型逆转录病毒。利用含有这两种病毒的包装信号的载体，可以生成含有这两种rna遗传信息的DNA原病毒。这是第一个实验证据，表明来自不同逆转录病毒的RNA可以相互包装和交换遗传信息。
Sequence analysis suggests that ancient recombination events may have occurred between genetically distinct retroviruses. An experimental system was utilized to explore the genetic interaction between different viruses. Moloney murine sarcoma virus and spleen necrosis virus are type C retroviruses that belong to different subgenera. With vectors containing packaging signals from these two viruses, DNA proviruses containing genetic information from both RNAs can be generated. This is the first experimental evidence to indicate that RNA from different retroviruses can copackage and exchange genetic information.