How anchoring proteins shape pain.
How anchoring proteins shape pain.
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DOI：
10.1016/j.pharmthera.2014.04.001
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发表时间：
2014-09
影响因子：
13.5
通讯作者：
M. Fischer;P. McNaughton
中科院分区：
文献类型：
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作者：
M. Fischer;P. McNaughton
细胞对外部刺激的反应性可以通过激活膜受体的细胞外介质来改变，进而通过钙、环核苷酸、膜脂质或酶活性向细胞内空间发出信号。这些信号事件触发级联反应，导致效应物，其可以是通道、酶或转录因子。当这些细胞内事件通过锚定蛋白保持紧密接近时，它们的有效性得到增强，锚定蛋白将信号分子（如激酶）与它们的靶标组装在一起，并以这种方式提高细胞内信号传导的速度和精度。A激酶锚定蛋白（AKAP）家族是最初因其将蛋白激酶A与其靶点结合的能力而命名的衔接蛋白，但现在已经发现了几种与AKAP结合的其他酶，并且已经描述了各种各样的靶结构。本文综述了参与疼痛信号传导的锚定蛋白。主要锚定蛋白及其离子通道的目标在初级感觉神经元疼痛刺激（伤害感受器）进行了讨论。
Cellular responsiveness to external stimuli can be altered by extracellular mediators which activate membrane receptors, in turn signalling to the intracellular space via calcium, cyclic nucleotides, membrane lipids or enzyme activity. These signalling events trigger a cascade leading to an effector which can be a channel, an enzyme or a transcription factor. The effectiveness of these intracellular events is enhanced when they are maintained in close proximity by anchoring proteins, which assemble complexes of signalling molecules such as kinases together with their targets, and in this way enhance both the speed and the precision of intracellular signalling. The A kinase anchoring protein (AKAP) family are adaptor proteins originally named for their ability to associate Protein Kinase A and its targets, but several other enzymes bound by AKAPs have now been found and a wide variety of target structures has been described. This review provides an overview of anchoring proteins involved in pain signalling. The key anchoring proteins and their ion channel targets in primary sensory neurons responding to painful stimuli (nociceptors) are discussed.