A prospective study of the psychobehavioral factors responsible for a change from non-patient irritable bowel syndrome to IBS patient status
A prospective study of the psychobehavioral factors responsible for a change from non-patient irritable bowel syndrome to IBS patient status
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DOI：
10.1186/1751-0759-2-16
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发表时间：
2008-01-01
影响因子：
2.1
通讯作者：
Nomura, Shinobu
中科院分区：
文献类型：
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作者：
Fujii, Yasushi;Nomura, Shinobu
背景资料：为了调查非患者肠易激综合征（IBS）向IBS的变化并确定预测IBS发病的因素，对个体生物因素、心理因素、行为因素和环境因素进行了检查。方法：受试者为105名非患者IBS（男= 59，女= 46，平均年龄：21.49 ± 2.37），其中以便秘为主型68例，便秘为主型37例，分别选自1，409名大学生和技术学院的使用问卷的基础上罗马II诊断标准。随访3年，连续观察12次IBS患者的各种特征和症状。结果：3年中，37例（35.24%）非患者IBS转为IBS，其中腹泻型28例，便秘型9例。26例（24.76%）非患者IBS患者症状消失。根据量化方法II（判别分析），采用压力源、两种压力应对方式、认知评价、饮食习惯、睡眠时间和心理虐待7个因素作为IBS发病的预测模型，并证实其对IBS的预测作用。结论：非患者型IBS是一种可转变为IBS或无症状者的可变状态。大多数无症状的非患者IBS受试者的症状持续时间为6个月或更短。此外，非患者IBS受试者的症状持续时间越长，转变为IBS的风险就越高。研究结果表明，尽早识别和接近非患者IBS以预防IBS发作是有用的。必须指出的是，在本研究中被调查的人只有以便秘为主和以便秘为主的类型。因此，本研究的发现仅限于这两种类型。包括混合型在内的进一步研究是必要的。
Background: To investigate non-patient irritable bowel syndrome (IBS) change to IBS and to determine factors predictive of the onset of IBS, individual biological factors, psychological factors, behavioral factors, and environmental factors were examined.Methods: The subjects were 105 non-patient IBS (male = 59, female = 46, average age: 21.49 +/- 2.37), including 68 of the diarrhea-predominant type and 37 of the constipation-predominant type selected from 1,409 university and technical college students by use of a questionnaire based on the Rome II diagnostic criteria. The subjects were followed for three years, and various characteristics and IBS symptoms were serially observed (12 times). The IBS incidence rate was calculated.Results: During the three years, 37 non-patient IBS (35.24%) changed to IBS: 28 diarrhea-predominant type and 9 constipation-predominant type. All IBS symptoms disappeared in 26 non-patient IBS subjects (24.76%). According to quantification method II (discriminant analysis), seven factors (stressor, two kinds of stress coping styles, cognitive appraisal, eating habits, sleeping time, and psychologically abuse) were adopted as a predictive model for IBS incidence and were confirmed as predictive of IBS.Conclusion: The results of this research show that non-patient IBS is a changeable state that can change into IBS or persons without symptoms. Most of the non-patient IBS subjects who became asymptomatic had had symptoms for six months or less. Furthermore, the longer a non-patient IBS subject had symptoms, the higher the risk of a change to IBS became. The findings suggest the usefulness of identifying and approaching non-patient IBS as early as possible to prevent the onset of IBS. It must be noted that the persons surveyed in the present study had only the diarrhea-predominant and constipation-predominant types. Therefore, the findings of the present study are limited only these two types. Further study including the mixed type is needed.