Rash produced by mouse cytomegalovirus
Rash produced by mouse cytomegalovirus
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小鼠巨细胞病毒引起的皮疹
DOI：
10.1128/iai.41.1.352-357.1983
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发表时间：
1983
影响因子：
3.1
通讯作者：
Cedric A. Mims
中科院分区：
文献类型：
--
作者：
Kong Teck CHONGt;Cedric A. Mims
小鼠静脉注射大剂量鼠巨细胞病毒后4天出现明显皮疹。常规组织学显示细胞浸润、血管损伤和出血。免疫荧光染色显示真皮而非表皮感染，这似乎是在循环病毒或含病毒白细胞定位于小血管后开始的。皮疹伴有血清中高水平的补体需要中和抗体和肾小球中含有免疫球蛋白G、免疫球蛋白M和补体的免疫复合物的广泛沉积。当小鼠被眼镜蛇毒因子耗尽补体时，当环磷酰胺治疗降低抗体反应时，或者当给予前列腺素抑制剂（吲哚美辛）时，皮疹的严重程度要轻得多。直接病毒损伤和炎症和免疫反应的病变的发生中的作用进行了讨论。
A striking rash was produced in mice 4 days after intravenous injection of large doses of murine cytomegalovirus. Routine histology showed cell infiltration, vascular damage, and hemorrhage. Immunofluourescent staining showed dermal but not epidermal infection, and this appeared to be initiated after the localization in small blood vessels of circulating virus or of virus-containing leukocytes. The rash was accompanied by a high level of complement-requiring neutralizing antibodies in the serum and extensive deposition of immune complexes in the renal glomeruli containing immunoglobulin G, immunoglobulin M, and complement. When mice were depleted of complement by cobra venom factor, when antibody responses were reduced by cyclophosphamide treatment, or when a prostaglandin inhibitor (indomethacin) was given, the rash was much less severe. The role of direct viral damage and inflammatory and immune responses in the genesis of the lesions is discussed.