Expression of DNA-dependent protein kinase catalytic subunit and Ku80 in developing human brains: implication of DNA-repair in neurogenesis
Expression of DNA-dependent protein kinase catalytic subunit and Ku80 in developing human brains: implication of DNA-repair in neurogenesis
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DOI：
10.1016/s0304-3940(00)01462-2
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发表时间：
2000-10-13
影响因子：
2.5
通讯作者：
Takeshita, K
中科院分区：
文献类型：
--
作者：
Oka, A;Takashima, S;Takeshita, K
我们研究了DNA依赖性蛋白激酶催化亚基（DNA-PKcs）和Ku 80在发育中人脑中的表达，这两种蛋白都被认为参与了DNA双链断裂（DSB）的修复。它们的表达有很好的相关性，并观察到最高的免疫反应性在有丝分裂后的大脑皮层中的未成熟神经元，以及在脑室周围胚层的祖细胞。在发育过程中反应性逐渐降低。我们的研究结果支持的概念，DSB是在人类中枢神经系统的个体发育过程中产生的。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
We investigated expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku80 in developing human brain, both of which have been suggested to be involved in the repair of DNA double-strand break (DSB). Their expressions were well correlated, and the highest immunoreactivity was observed in post-mitotic immature neurons in the cerebral cortex as well as in progenitors in the periventricular germinal layer. The reactivity gradually decreased during development. Our results support the notion that DSB is generated during the ontogeny of the human central nervous system. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.