Alterations in tRNA Metabolism as Markers of Neoplastic Transformation
Alterations in tRNA Metabolism as Markers of Neoplastic Transformation
复制标题
tRNA 代谢的改变作为肿瘤转化的标志
DOI：
10.1007/978-1-4684-4454-4_21
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发表时间：
1983
期刊：
影响因子：
2.9
通讯作者：
M. Grever
中科院分区：
文献类型：
--
作者：
R. Trewyn;M. Elliott;R. Glaser;M. Grever
当细胞发生肿瘤性转化时，观察到tRNA修饰和催化剂的许多变化。其中某些变化的性质已经确定，而另一些变化则需要进一步定性。参与tRNA大分子修饰的酶，tRNA甲基转移酶，在肿瘤转化过程中表现出特异质的变化。这些改变包括酶比活性的增加以及恶性组织中不同tRNA甲基转移酶的出现1，2。从转化细胞中分离的酶在体外观察到的增加的tRNA甲基转移酶活性和能力也可以与体内特定tRNA iso接受物质的甲基化增加相关，尽管不是总tRNA。
Numerous changes in tRNA modification and catabolism are observed when cells undergo neoplastic transformation. The nature of certain of these changes is well established, while others require further characterization. Enzymes involved in the macromolecular modification of tRNA, the tRNA methyltransferases, exhibit idiosyncratic alterations during neoplastic transformation. These alterations include increases in enzyme specific activity as well as the appearance of different tRNA methyltransferases in the malignant tissue1,2. The increased tRNA methyltransferase activity and capacity observed in vitro for the enzymes isolated from transformed cells can also be correlated to increased methylation of specific tRNA iso accepting species, although not total tRNA, in vivo 3.