FIBRONECTIN STRUCTURE AND ASSEMBLY
FIBRONECTIN STRUCTURE AND ASSEMBLY
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DOI：
10.1016/0955-0674(94)90090-6
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发表时间：
1994-10-01
影响因子：
7.5
通讯作者：
CAMPBELL, ID
中科院分区：
文献类型：
--
作者：
POTTS, JR;CAMPBELL, ID
最近在确定重要基质蛋白纤连蛋白的结构和组装方面取得了重大进展，纤连蛋白是一种主要由 Fn1、Fn2 和 Fn3 三个模块单元构成的分子。原子分辨率结构现在可用于所有三个单一模块、Fn1 和 Fn3 模块对以及纤连蛋白单体之间的二硫键连接。结合新的结合和突变研究的结果，新的结构信息使完整纤连蛋白的结构/功能关系有了更清晰的认识。
Significant progress has been made recently in the determination of the structure and assembly of the important matrix protein fibronectin, a molecule mainly constructed from three modular units denoted Fn1, Fn2 and Fn3. Atomic resolution structures are now available for all three single modules, for Fn1 and Fn3 module pairs, and for the disulphide-linked join between fibronectin monomers. Combined with results from new binding and mutation studies, the new structural information is leading to a clearer view of structure/function relationships in intact fibronectin.