A mechanistic overview of taste bud maintenance and impairment in cancer therapies.
A mechanistic overview of taste bud maintenance and impairment in cancer therapies.
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DOI：
10.1093/chemse/bjab011
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发表时间：
2021-03
期刊：
影响因子：
3.5
通讯作者：
D. Gaillard;L. Barlow
中科院分区：
文献类型：
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作者：
D. Gaillard;L. Barlow
自世纪早期以来，癌症治疗的进展显著改善了疾病预后。尽管如此，癌症治疗通常与副作用有关，这些副作用可能会对患者的健康产生负面影响并扰乱治疗过程。在主要的副作用中，味觉障碍与抑郁、营养不良和病态体重减轻有关。虽然相对常见，但与癌症治疗相关的味觉障碍仍然知之甚少。在这里，我们回顾了目前的知识相关的分子机制的味觉维持和破坏的背景下，癌症治疗。
Since the early 20 th century, progress in cancer therapies has significantly improved disease prognosis. Nonetheless, cancer treatments are often associated with side effects that can negatively affect patient wellbeing and disrupt the course of treatment. Among the main side effects, taste impairment is associated with depression, malnutrition and morbid weight loss. Although relatively common, taste disruption associated with cancer therapies remains poorly understood. Here, we review the current knowledge related to the molecular mechanisms underlying taste maintenance and disruption in the context of cancer therapies.