Interactions of guanine and guanosine hydrates with quinones: a laser flash photolysis and magnetic field effect study.
Interactions of guanine and guanosine hydrates with quinones: a laser flash photolysis and magnetic field effect study.
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DOI：
10.1021/jp711846n
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发表时间：
2008-05
期刊：
影响因子：
--
通讯作者：
A. Bose;D. Dey;S. Basu
中科院分区：
文献类型：
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作者：
A. Bose;D. Dey;S. Basu
利用激光闪光光解和外加磁场研究了两种醌分子，即9，10-蒽醌（AQ）和2-甲基1，4-萘醌（MQ），与DNA碱基之一鸟嘌呤（G）及其核苷鸟苷水合物（dG）的相互作用。在有机均相介质中，G主要与两种醌类化合物发生夺氢反应，而dG在夺氢的同时沿着光诱导电子转移（PET）.另一方面，在SDS培养基中，G支持PET与AQ，但不支持MQ。而dG对AQ和MQ的行为随介质的改变而保持不变。所有这些观察结果已被解释的基础上的自由基离子对的稳定性和醌的大小的差异，这可以影响相互作用的分子之间的接近距离。
Laser flash photolysis and an external magnetic field have been used to study the interaction of two quinone molecules, namely, 9,10-anthraquinone (AQ) and 2-methyl 1,4-naphthoquinone, commonly known as menadione (MQ), with one of the DNA bases, guanine (G) and its nucleoside guanosine hydrate (dG). In organic homogeneous medium, it has been observed that G undergoes a predominant hydrogen (H) abstraction reaction with both the quinones while dG supports photoinduced electron transfer (PET) along with H abstraction. On the other hand, in SDS medium, G supports PET with AQ but not with MQ. However, behavior of dG remains unperturbed toward AQ and MQ with the change in medium. All of these observations have been explained on the basis of stabilization of radical ion pair and difference in size of the quinones, which can affect the distance of approach among the interacting molecules.