Growth factors involve in cellular proliferation, differentiation and migration during prostate cancer metastasis.
Growth factors involve in cellular proliferation, differentiation and migration during prostate cancer metastasis.
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发表时间：
2019
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通讯作者：
I. Isali;Mohammed Adel Ali Al-Sadawi;A. Qureshi;Ahmad O Khalifa;M. K. Agrawal;S. Shukla
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作者：
I. Isali;Mohammed Adel Ali Al-Sadawi;A. Qureshi;Ahmad O Khalifa;M. K. Agrawal;S. Shukla
生长因子在细胞增殖、胚胎发育调控和细胞分化中起着积极的作用。水平改变的生长因子促进正常细胞的恶性转化。在治疗恶性肿瘤方面，药物、抑制剂和抗改变生长因子的单抗已经取得了重大进展。此外，前列腺癌中这些改变的生长因子会增加类固醇激素水平，从而促进进展。虽然这篇综述强调了前列腺癌发生中主要涉及的生长因子，但这将使我们能够更好地设计抑制前列腺癌进展的治疗策略。
Growth factors play active role in cells proliferation, embryonic development regulation and cellular differentiation. Altered level growth factors promote malignant transformation of normal cells. There has been significant progress made in form of drugs, inhibitors and monoclonal antibodies against altered growth factor to treat the malignant form of cancer. Moreover, these altered growth factors in prostate cancer increases steroidal hormone levels, which promotes progression. Though this review we are highlighting the majorly involved growth factors in prostate carcinogenesis, this will enable to better design the therapeutic strategies to inhibit prostate cancer progression.