Real-Time PCR Quantification of Methanobrevibacter oralis in Periodontitis
Real-Time PCR Quantification of Methanobrevibacter oralis in Periodontitis
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DOI：
10.1128/jcm.02863-12
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发表时间：
2013-03-01
影响因子：
9.4
通讯作者：
Drancourt, Michel
中科院分区：
文献类型：
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作者：
Bringuier, Amelie;Khelaifia, Saber;Drancourt, Michel
尽管对照组（3/10）和患者（12/22）之间的患病率无显著差异（P = 0.2， Fisher检验），但用于定量口腔甲烷预防菌的实时PCR检测显示，其接种量与牙周炎严重程度显著相关（P = 0.003）。口腔分枝杆菌负荷可作为牙周炎的生物标志物。
A real-time PCR assay developed to quantify Methanobrevibacter oralis indicated that its inoculum significantly correlated with periodontitis severity (P = 0.003), despite a nonsignificant difference in prevalence between controls (3/10) and patients (12/22) (P = 0.2, Fisher test). The M. oralis load can be used as a biomarker for periodontitis.