Evidence on the retrograde neurotoxicity of doxorubicin
Evidence on the retrograde neurotoxicity of doxorubicin
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DOI：
10.1016/0304-3940(85)90188-0
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发表时间：
1985-01
影响因子：
2.5
通讯作者：
D. Kooy;K. A. Zito;D. Roberts
中科院分区：
文献类型：
--
作者：
D. Kooy;K. A. Zito;D. Roberts
阿霉素是一种荧光逆行神经毒素，可杀死传入尾壳核注射部位的腹侧被盖和丘脑神经元。腹侧被盖和丘脑中的神经毒性作用通过在纹状体中注射部位的尾部切割大型冠状刀来防止，这表明阿霉素的逆行转运对于传入神经元的死亡是必要的。在纹状体中，注射后14天多柔比星对传入神经元的神经毒性作用在数量上远大于对局部纹状体胞体的神经毒性作用（如通过多巴胺水平下降72%所评估的）（如通过谷氨酸脱羧酶活性下降22%所证明的）。多柔比星可能是一种有用的工具，用于通过逆行运输的方式选择性地破坏传入大脑中某个部位的神经元。
Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, suggesting that retrograde transport of doxorubicin is necessary for the death of afferent neurons. In the striatum the neurotoxic effects of doxorubicin 14 days post-injection were quantitatively much greater on afferent neurons (as assessed by a 72% drop in dopamine levels) than on local striatal perikarya (as evidenced by the small 22% drop in the activity of glutamic acid decarboxylase). Doxorubicin may be a useful tool for selectively destroying, by way of retrograde transport, neurons that are afferent to a site in the brain.