Lower pulmonary function and cerebral subclinical abnormalities detected by MRI - The atherosclerosis risk in communities study
Lower pulmonary function and cerebral subclinical abnormalities detected by MRI - The atherosclerosis risk in communities study
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DOI：
10.1378/chest.116.1.150
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发表时间：
1999-07-01
期刊：
影响因子：
9.6
通讯作者：
Heiss, G
中科院分区：
文献类型：
--
作者：
Liao, D;Higgins, M;Heiss, G
研究目标：调查肺功能与 (1) 脑梗死和 (2) 白质病变 (WML) 之间的关联，通过 MRI 识别并被认为代表动脉硬化、全身灌注不足或脑缺血的亚临床病变。设计：基于人群的横断面研究。背景：美国的两个社区。参与者：1,917 名 55 至 72 岁的非裔美国人和白人男性和女性样本社区动脉粥样硬化风险研究队列第二次随访检查中选出的 3 岁儿童。干预措施：观察性研究。测量和结果：根据美国胸科学会标准评估肺功能指标 FEV1 和 FVC。通过 MRI 评估亚临床脑梗死和 WML，调整年龄、种族、性别、身高和身高平方后，非吸烟者 FEV1 的 1-SD 下降与梗塞比值比（95% 置信区间 [CI]，1.31 至 2.03）相关，梗塞比值比为 1.63，与梗塞比值比为 1.35（95% CI，1.08 至 1.69）相关。 WML。在 FEV1 最低四分位的人中，15% 患有梗塞和 WML，而 FEV1 最高四分位的人中只有 6% 患有梗塞和 WML。使用 FVC 作为肺功能指标也观察到了一致的关联。在当前吸烟者中也发现了类似的关联模式。对心血管疾病、合并症或认知功能等传统危险因素的额外调整并没有改变这种关联。结论：这项基于人群的研究结果表明，较低的肺功能与亚临床脑异常有关。
Study objectives: To investigate the association between pulmonary function and (1) cerebral infarction and (2) white matter lesions (WMLs), identified by MRI and believed to represent subclinical lesions of arteriosclerosis, generalized hypoperfusion, or ischemia of the brain.Design: Population-based, cross-sectional study.Setting: Two communities in the United States.Participants: A sample of 1,917 African-American and white men and women 55 to 72 years old who were selected from the second follow-up examination of the Atherosclerosis Risk in Communities Study cohort.Interventions: Observational study.Measurements and results: The lung function indexes, FEV1 and FVC, were assessed according to American Thoracic Society criteria. Subclinical cerebral infarction and WMLs were assessed by MRI, After adjusting for age, ethnicity, gender, height, and height squared, a 1-SD decrease of FEV1 in nonsmokers was associated with odds ratios (95% confidence interval [CI], 1.31 to 2.03) of 1.63 for infarction and 1.35 (95% CI, 1.08 to 1.69) for WMLs. Of those in the lowest quartile of FEV1, 15% had infarction and WMLs, in contrast to 6% of the individuals in the upper most quartile of FEV1. Consistent associations were also observed by using FVC as an index of pulmonary function. Similar patterns of association were found among current smokers, The associations were not altered by additional adjustment of conventional risk factors of cardiovascular disease, comorbidity, or cognitive function.Conclusion: The results from this population-based study suggest that lower pulmonary function is associated with subclinical cerebral abnormalities.