Networked Zwitterionic Durable Antibacterial Surfaces
Networked Zwitterionic Durable Antibacterial Surfaces
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DOI：
10.1021/acsabm.9b00982
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发表时间：
2020-02-17
影响因子：
4.7
通讯作者：
Ghasemi, Hadi
中科院分区：
文献类型：
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作者：
Huang, Zixu;Nazifi, Sina;Ghasemi, Hadi
近年来，由于传统的杀菌浸出和接触杀灭表面在实际应用中的缺点，对细菌排斥表面的开发进行了深入的研究。在这些细菌排斥方法中，两性离子聚合物由于其优异的防污性能而被广泛研究，但其耐久性限制了其广泛使用，因为大多数表面是通过原子转移自由基聚合（ATRP）构建聚合物刷而开发的。在这项研究中，我们开发了两性离子聚合物表面所需的长期使用的机械和化学耐久性，通过简单的共混物的聚（磺基甜菜碱甲基丙烯酸酯）（PSBMA）/聚（醚砜）（PES）半互穿网络微凝胶与疏水性PES聚合物基质。结果表明，所制备的表面可以有效地诱导水化层，从而通过抵抗非特异性蛋白质吸附来减少细菌的附着。在流动和静态条件下研究了大肠杆菌和金黄色葡萄球菌的细菌粘附。这项工作为开发具有防污性能的耐用抗菌表面树立了典范。
Recently, intensive research has been conducted on the development of bacterial repelling surfaces because of the disadvantages of the conventional bactericidal leaching and contact-killing surfaces for practical application. Among these bacteria-repelling methodologies, zwitterionic polymers were widely investigated because of its excellent nonfouling properties, but its durability has limited its widespread use since most of the surfaces were developed by constructing polymer brushes via atom transfer radical polymerization (ATRP). In this study, we developed zwitterionic polymer surfaces with desirable mechanical and chemical durability for long-term use through simple blending of poly(sulfobetaine methacrylate) (PSBMA)/poly(ether sulfone) (PES) semi-interpenetrated networked microgels with hydrophobic PES polymer matrix. Results show that the as-prepared surfaces can efficiently induce hydration layers and, thus, reduce the bacterial attachment through resisting nonspecific protein adsorption. The bacterial adhesion for Escherichia coli and Staphylococcus aureus was investigated under both flow and static conditions. This work has set a paradigm for developing durable antibacterial surfaces with nonfouling properties.