Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits
Feasibility of blood oxygenation level-dependent MR imaging to monitor hepatic transcatheter arterial embolization in rabbits
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DOI：
10.1097/01.rvi.0000182179.87340.d7
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发表时间：
2005-11-01
影响因子：
2.9
通讯作者：
Omary, RA
中科院分区：
文献类型：
--
作者：
Rhee, TK;Larson, AC;Omary, RA
血氧水平依赖（BOLD）磁共振（MR）成像是一种评估组织氧输送变化的无创方法。假设BOLD磁共振成像可以检测聚乙烯醇颗粒肝动脉栓塞后兔VX2肝肿瘤氧合的变化。在四个离散的VX2肝肿瘤中，表观横向弛豫时间平均减少具有统计学意义，从栓塞前的55毫秒减少到栓塞后的41毫秒（P < 0.01）。这种减少与肝肿瘤氧合的减少相对应。使用BOLD磁共振成像监测栓塞后肝肿瘤氧合变化是可行的。在未来的研究中，这些功能性磁共振成像测量可能作为治疗的终点。
Blood oxygenation level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method to assess changes in oxygen delivery to tissues. It was hypothesized that BOLD MR imaging can detect changes in rabbit VX2 liver tumor oxygenation after hepatic artery embolization with polyvinyl alcohol particles. In four discrete VX2 liver tumors, a statistically significant mean reduction in apparent transverse relaxation time was shown, from 55 milliseconds before embolization to 41 milliseconds after embolization (P < .01). This reduction corresponded to a decrease in hepatic tumor oxygenation. The use of BOLD MR imaging to monitor changes in hepatic tumor oxygenation after embolization is feasible. These functional MR imaging measurements of hypoxia may be targeted as an endpoint for therapy in future studies.