Nucleolar organiser region associated proteins in cutaneous melanotic lesions: a quantitative study.
Nucleolar organiser region associated proteins in cutaneous melanotic lesions: a quantitative study.
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皮肤黑色素病变中核仁组织区相关蛋白：定量研究。
DOI：
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发表时间：
1987
影响因子：
3.4
通讯作者：
N. Skilbeck
中科院分区：
文献类型：
--
作者：
J. Crocker;N. Skilbeck
使用银染技术，在一系列真皮黑色素病变的常规处理石蜡切片中鉴定出核仁组织者区域。该技术显示了嗜银 NOR 相关蛋白 (AgNOR)，其在细胞核中表现为黑点。尽管原位黑色素癌、黑色素癌本身和恶性雀斑样痣的细胞核含有相似数量的 AgNOR，但在黑色素癌中，每个细胞核平均含有 7.9 个 AgNOR，而在痣细胞痣中，这一数字为 1.2。大多数组织病理学家都不知道 AgNOR 方法，但它也许可以定量或半定量地用于协助诊断皮肤（和其他地方）的黑色素病变。
Using a silver staining technique, nucleolar organiser regions were identified in routinely processed paraffin sections of a range of dermal melanotic lesions. The technique shows argyrophilic NOR associated proteins (AgNORs), which are seen in nuclei as black dots. Although the nuclei of melanocarcinoma in situ, melanocarcinoma per se, and lentigo maligna contained similar numbers of AgNORs, in melanocarcinomas a mean of 7.9 AgNORs per nucleus was found, while in naevocellular naevi, this figure was 1.2. The AgNOR method, which is unknown to most histopathologists, could perhaps be used quantitatively or semiquantitatively to assist in the diagnosis of melanotic lesions in the skin (and elsewhere).
影响因子：
2.9
作者：
OLSON, MOJ;THOMPSON, BA
通讯作者：
THOMPSON, BA