ASAP: the Alternative Splicing Annotation Project
ASAP: the Alternative Splicing Annotation Project
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DOI：
10.1093/nar/gkg029
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Xing, Y
中科院分区：
文献类型：
--
作者：
Lee, C;Atanelov, L;Xing, Y
最近，基因组学分析表明，选择性剪接广泛存在于哺乳动物基因组中（30-60%的基因报告具有多种异构体），并且可能是其最重要的功能调节机制之一。然而，与其他基因组学数据，如基因组注释，SNP，或基因表达相比，存在相对较少的数据库基础设施的研究选择性剪接。我们已经建立了一个在线数据库ASAP（选择性剪接注释项目）的生物学家访问和挖掘的巨大财富的选择性剪接信息来自基因组学和蛋白质组学。ASAP是基于人类可变剪接的全基因组分析（发现30793个可变剪接关系），从表达序列到基因组序列的详细比对。ASAP提供了精确的基因外显子内含子结构，选择性剪接，选择性剪接形式的组织特异性，以及选择性剪接产生的蛋白质异构体序列。此外，它可以帮助生物学家设计探针序列，以区分特定的mRNA亚型。ASAP旨在成为一个社区资源，用于协作注释选择性剪接形式、其调节和生物学功能。ASAP的URL是http://www.bioinformatics.ucla.edu/ASAP。
Recently, genomics analyses have demonstrated that alternative splicing is widespread in mammalian genomes (30-60% of genes reported to have multiple isoforms), and maybe one of their most important mechanisms of functional regulation. However, by comparison with other genomics data such as genome annotation, SNPs, or gene expression, there exists relatively little database infrastructure for the study of alternative splicing. We have constructed an online database ASAP (the Alternative Splicing Annotation Project) for biologists to access and mine the enormous wealth of alternative splicing information coming from genomics and proteomics. ASAP is based on genome-wide analyses of alternative splicing in human (30793 alternative splice relationships found) from detailed alignment of expressed sequences onto the genomic sequence. ASAP provides precise gene exon intron structure, alternative splicing, tissue specificity of alternative splice forms, and protein isoform sequences resulting from alternative splicing. Moreover, it can help biologists design probe sequences for distinguishing specific mRNA isoforms. ASAP is intended to be a community resource for collaborative annotation of alternative splice forms, their regulation, and biological functions. The URL for ASAP is http://www.bioinformatics.ucla.edu/ASAP.