The pacemaker current (I(f)) plays an important role in regulating SA node pacemaker activity.
The pacemaker current (I(f)) plays an important role in regulating SA node pacemaker activity.
复制标题
起搏器电流 (I(f)) 在调节 SA 节点起搏器活动中起着重要作用。
DOI：
10.1016/s0008-6363(95)00029-1
复制
发表时间：
1995
影响因子：
10.8
通讯作者：
Dario DiFrancesco
中科院分区：
文献类型：
--
作者：
Dario DiFrancesco
舒张期缓慢的“起搏器”去极化是心脏起搏器细胞自发活动的基础。是什么机制驱动的？任何去极化都需要净向内电流，而“衰减”的向外Kf电流代表起搏器机制的想法可能是误导的，因为向外电流只能超极化。寻找起搏器机制意味着寻找在MDP范围内流动的内向组件。我们将讨论两种可能的候选电流：超极化激活的If（通常称为“起搏器”）电流和与时间无关的“背景”Ib电流。其他竞争者，如钙成分，在去极化时激活，不太可能正常参与早期舒张期去极化。
The diastolic, slow ‘‘pacemaker’’depolarisation underlies spontaneous activity in cardiac pacemaker cells. Which mechanism drives it? Any depolarisation requires a net inward current, and the idea that a “decaying” outward Kf current represents a pacemaker mechanism may be misleading since outward currents can only hyperpolarise. Searching for a pacemaker mechanism implies looking for an inward component flowing in the MDP range. We shall discuss two possible candidates: the hyperpolarisationactivated If (often termed “pacemaker”) current, and the time-independent “background” Ib current. Other contenders, such as calcium components, activate on depolarization and are unlikely to contribute normally to early diastolic depolarisation.