Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
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DOI：
10.1023/a:1012338828418
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发表时间：
2001-11-01
影响因子：
3.1
通讯作者：
Lindor, KD
中科院分区：
文献类型：
--
作者：
Nehra, V;Angulo, P;Lindor, KD
本研究旨在确定非酒精性脂肪性肝炎（NASH）与血清游离脂肪酸水平、胆碱缺乏或乳糜泻之间是否存在关联。招募了47例经肝活检证实为NASH的患者。测定了所有患者的血清总游离脂肪酸和抗肌内膜抗体，同时测定了29例患者的血浆游离胆碱和磷脂结合胆碱。血清总游离脂肪酸浓度与女性性别和血清白蛋白浓度显著相关。肝活检显示有严重纤维化的患者血清游离脂肪酸浓度显著高于无严重纤维化的患者。血浆游离胆碱和磷脂结合胆碱水平正常，且血浆游离胆碱或磷脂结合胆碱浓度与肝损伤严重程度之间未发现显著相关性。47例NASH患者中仅有1例抗肌内膜抗体滴度呈阳性。总之，在NASH中发现血清游离脂肪酸浓度升高，且与更严重的肝脏疾病发展相关。通过抗肌内膜抗体检测，胆碱缺乏和乳糜泻均与NASH无关。
The aim of this study was to determine if a relationship exists between nonalcoholic steatohepatitis (NASH) and serum levels of free fatty acids, choline deficiency, or celiac disease. Forty-seven patients with liver biopsy proven NASH were enrolled. Total serum free fatty acids and anti-endomysial antibodies were determined in all patients, while plasma free and phospholipid-bound choline were determined in 29 patients. Total serum free fatty acid concentration correlated significantly with female gender and serum albumin concentration. Patients with severe fibrosis on liver biopsy had significantly greater serum concentration of free fatty acids than patients without severe fibrosis. Plasma free and phospholipid-bound choline levels were normal and. no significant correlation was found between the concentration of plasma free or phospholipid bound choline, and the severity of liver damage. Only one of the 47 patients with NASH had a positive titer for the anti-endomysial antibody. In conclusion, increased serum concentrations of free fatty acids were found in NASH and were associated with development of more severe liver disease. Neither choline deficiency nor celiac sprue by anti-endomysial antibody testing was associated with NASH.