Implications of Perioperative Polypharmacy in Adolescents Undergoing Bariatric Surgery: a Single-Center Experience.
Implications of Perioperative Polypharmacy in Adolescents Undergoing Bariatric Surgery: a Single-Center Experience.
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围手术期多重用药对接受减肥手术的青少年的影响：单中心经验。
DOI：
10.1007/s11695-020-04456-w
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发表时间：
2020
期刊：
影响因子：
2.9
通讯作者：
vandenAnker,JohannesN
中科院分区：
文献类型：
--
作者：
Williams,ElaineF;Vaughns,JanelleD;Mackey,EleanorR;Muret,JaneC;Nadler,EvanP;vandenAnker,JohannesN
寻求减肥手术的青少年可能有先前存在的精神病诊断，他们使用慢性药物治疗。为了提高对极端肥胖青少年围手术期多药的认识，我们对2010年2月至2017年5月在儿童国家卫生系统（CNHS）接受腹腔镜袖胃切除术的患者进行了回顾性研究。共有167名青少年患者先前有精神疾病诊断，包括抑郁症（50%）、焦虑症（23%）、多动症（23%）和暴食症（11%）。用于治疗这些诊断的药物包括选择性血清素再摄取抑制剂（SSRIs）和血清素-去甲肾上腺素再摄取抑制剂（SNRIs）。此外，所有患者围手术期给予芬太尼、昂丹西琼、吗啡和对乙酰氨基酚。虽然没有发现危及生命的药物-药物相互作用（ddi）症状，但在这些患者中联合使用许多不同的强效药物值得注意。
Adolescents seeking bariatric surgery may present with pre-existing psychiatric diagnoses for which they use chronic medications. To heighten awareness concerning perioperative polypharmacy in adolescents with extreme obesity, we conducted a retrospective review of patients undergoing laparoscopic sleeve gastrectomy between February 2010 and May 2017 at Children’s National Health System (CNHS). A total of 167 adolescent patients had pre-existing psychiatric diagnoses which included depression (50%), anxiety (23%), ADHD (23%), and binge eating disorder (11%). Medications prescribed to treat these diagnoses included selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). Additionally, all patients were given fentanyl, ondansetron, morphine, and acetaminophen perioperatively. Although no life threatening symptoms of drug-drug interactions (DDIs) were appreciated, the combined use of many different potent drugs in these patients warrants attention.