Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems.
Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems.
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预期行为的功能神经解剖学：感觉驱动和记忆驱动系统之间的分离。
DOI：
10.1093/cercor/bhi073
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Sweeney,JohnA
中科院分区：
文献类型：
--
作者：
Simo,LuciaS;Krisky,ChristineM;Sweeney,JohnA
预测可预测刺激的能力允许更快的反应。预测性扫视（PRED）任务已被证明可以快速诱导人类的这种预期行为。在PRED任务中，受试者跟踪以固定时间间隔在固定位置之间来回跳跃的视觉目标。在该任务期间，随着受试者预期目标出现，扫视延迟从200 ms下降到<80 ms。扫视潜伏期的这种变化表明受试者的行为从感官驱动转变为记忆驱动。我们进行了功能磁共振成像研究，10名健康成人执行PRED任务，使用标准的区组设计。我们比较了PRED任务与视觉引导扫视（VGS）任务，使用不可预测的目标匹配所需的扫视的数量，方向和幅度。我们的研究结果表明，在PRED任务中，前额叶，前辅助运动和前扣带皮层，海马，背内侧丘脑，纹状体和小脑的激活更大。VGS任务引起了皮质眼区和枕叶皮质的更大激活。这些结果表明，重要的分离之间的感觉和预测神经控制类似扫视眼球运动。由PRED任务引起的预期行为需要较少的感觉相关的处理活动，并由一个分布式的皮质-皮质下记忆系统，包括前额叶-纹状体电路subserved。
The ability to anticipate predictable stimuli allows faster responses. The predictive saccade (PRED) task has been shown to quickly induce such anticipatory behavior in humans. In a PRED task subjects track a visual target jumping back and forth between fixed positions at a fixed time interval. During this task, saccade latencies drop from ∼ 200 ms to <80 ms as subjects anticipate target appearance. This change in saccade latency indicates that subjects' behavior shifts from being sensory driven to being memory driven. We conducted functional magnetic resonance imaging studies with 10 healthy adults performing the PRED task using a standard block design. We compared the PRED task with a visually guided saccade (VGS) task using unpredictable targets matched for number, direction and amplitude of required saccades. Our results show greater activation during the PRED task in the prefrontal, pre-supplementary motor and anterior cingulate cortices, hippocampus, mediodorsal thalamus, striatum and cerebellum. The VGS task elicited greater activation in the cortical eye fields and occipital cortex. These results demonstrate the important dissociation between sensory and predictive neural control of similar saccadic eye movements. Anticipatory behavior induced by the PRED task required less sensory-related processing activity and was subserved by a distributed cortico-subcortical memory system including prefronto-striatal circuitry.