Increased vascular permeability in rat nasal mucosa induced by substance P and stimulation of capsaicin-sensitive trigeminal neurons.
Increased vascular permeability in rat nasal mucosa induced by substance P and stimulation of capsaicin-sensitive trigeminal neurons.
复制标题
P 物质诱导大鼠鼻粘膜血管通透性增加并刺激辣椒素敏感的三叉神经元。
作者：
L. Lundblad;A. Saria;J. Lundberg;A. Ánggard
电刺激三叉神经的上颌支诱导血管通透性的增加，大分子和大鼠鼻粘膜间质水肿，所示的外渗的伊文思蓝。在接受过辣椒素治疗的动物中，三叉神经刺激的效果被消除了。局部应用辣椒素或P物质（SP）也诱导鼻粘膜中显著的伊文思蓝外渗。在辣椒素预处理的动物中，SP的作用仍然存在，而辣椒素诱导的通透性增加被取消。总之，辣椒素对鼻粘膜的化学刺激可能通过局部轴突反射诱导释放SP引起水肿。辣椒素敏感的含SP的鼻粘膜传入神经也可能参与各种类型鼻炎中出现的鼻充血的发病机制。
Electrical stimulation of the maxillary branches of the trigeminal nerve induced an increase in vascular permeability to macromolecules and an interstitial edema in the nasal mucosa of the rat, as indicated by extravasation of Evans blue. In animals that had been treated neonatally with capsaicin, the effect of trigeminal nerve stimulation was abolished. Local application of capsaicin or substance P (SP) also induced a significant Evans blue extravasation in the nasal mucosa. In capsaicin-pretreated animals the effect of SP was still present, while the permeability increase induced by capsaicin was abolished. In conclusion, chemogenic irritation of the nasal mucosa by capsaicin induces edema probably via a local axon reflex inducing release of SP. Capsaicin-sensitive SP-containing afferents in the nasal mucosa may also be involved in the pathogenesis of nasal congestion seen in various types of rhinitis.