Bioactive Glass for Large Bone Repair
Bioactive Glass for Large Bone Repair
复制标题
用于大骨修复的生物活性玻璃
DOI：
10.1002/adhm.201500447
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发表时间：
2015-12-30
影响因子：
10
通讯作者：
Fu, Qiang
中科院分区：
文献类型：
--
作者：
Jia, Weitao;Lau, Grace Y.;Fu, Qiang
人们一直在寻求新的生物医学材料来修复和再生由疾病或创伤引起的大节段性骨缺损。自体骨移植（ABG）仍然是骨修复的金标准，尽管其有限的供应和供体部位的发病率。目前合成骨移植的组织工程方法需要一种生物活性的陶瓷或聚合物支架，支架上装载有骨诱导和血管生成的生长因子，以及具有成骨特性的骨髓基质细胞（BMSCs）。不幸的是，这种方法有严重的缺点：支架的机械强度低，生长因子的成本高，缺乏最佳的生长因子递送策略。在这里，研究人员首次证明，单独一种合成材料可以像金标准ABG一样有效地修复大面积骨缺损。通过使用强而可吸收的生物活性玻璃支架，可以在没有生长因子或骨髓间充质干细胞的兔股骨节段性缺损模型中实现完全骨愈合和缺损桥接。新骨和血管的形成，在内部和周围支架，显示出优异的成骨和成骨的性质，这些支架类似于ABG。
There has been an ongoing quest for new biomedical materials for the repair and regeneration of large segmental bone defects caused by disease or trauma. Autologous bone graft (ABG) remains the gold standard for bone repair despite their limited supply and donor‐site morbidity. The current tissue engineering approach with synthetically derived bone grafts requires a bioactive ceramic or polymeric scaffold loaded with growth factors for osteoinduction and angiogenesis, and bone marrow stromal cells (BMSCs) for osteogenic properties. Unfortunately, this approach has serious drawbacks: the low mechanical strength of scaffolds, the high cost of growth factors, and a lack of optimal strategies for growth‐factor delivery. Here, it is shown that, for the first time, a synthetic material alone can repair large bone defects as efficiently as the gold standard ABG. Through the use of strong and resorbable bioactive glass scaffolds, complete bone healing, and defect bridging can be achieved in a rabbit femur segmental defect model without growth factors or BMSCs. New bone and blood vessel formation, in both inner and peripheral scaffolds, demonstrates the excellent osteoinductive and osteogenic properties of these scaffolds similar as ABG.