p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.
p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.
复制标题
p27：信号放松管制的晴雨表和靶向治疗反应的潜在预测因子。
DOI：
10.1158/1078-0432.ccr-10-0752
复制
发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Slingerland JM
中科院分区：
文献类型：
--
作者：
Wander SA;Zhao D;Slingerland JM
Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization and biological function. In human cancers, loss of the antiproliferative action of p27 can arise through reduced protein levels and/or cytoplasmic mislocalization leading to increased cell proliferation and/or cell migration, respectively. Reduced p27 expression levels and p27 mislocalization have potential prognostic and therapeutic implications in various types of human cancers. This review highlights mechanisms of functional deregulation of p27 by oncogenic signaling that provide an important molecular rationale for pathway targeting in cancer treatment.
