Genetic variants of SOX9 contribute to susceptibility of gliomas among Chinese population.
Genetic variants of SOX9 contribute to susceptibility of gliomas among Chinese population.
复制标题
SOX9 的遗传变异导致中国人群罹患神经胶质瘤的易感性。
DOI：
10.18632/oncotarget.11679
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发表时间：
2016-10-04
期刊：
影响因子：
--
通讯作者：
Tu Y
中科院分区：
文献类型：
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作者：
Wang L;Li G;Liu N;Wang Z;Xu X;Qi J;Ren D;Zhang P;Zhang Y;Tu Y
脑胶质瘤约占所有恶性脑肿瘤的80%，是严重的公共卫生问题。遗传因素和环境因素共同导致胶质瘤的发生，了解其遗传基础是预防肿瘤学的关键组成部分。然而，大多数神经胶质瘤癌变的遗传因素仍然很不清楚。在本研究中，我们系统地评估了SOX 9基因的遗传变异，在肿瘤的发展和分化中起着核心作用，是否有助于中国人群中胶质瘤的易感性，使用两阶段，病例对照研究。结果显示，在调整年龄、性别、癌症家族史、吸烟状况和饮酒状况后，SOX 9 rs 1042667与胶质瘤风险增加显著相关（等位基因C vs A：OR=1.25; 95% CI=1.11-1.40; P=1.2×10−4）。与AA基因型携带者相比，AC基因型（OR=1.37，95%CI =1.13-1.66）和CC基因型（OR=1.53，95%CI =1.22-1.91）均显著增加患胶质瘤的风险。这应该是第一个旨在评估SOX 9遗传变异与神经胶质瘤易感性之间关联的遗传关联研究。还需要对不同种族人群进行更多的功能和相关性研究，以进一步证实我们的结果。
Gliomas make up about 80% of all malignant brain tumors, and cause serious public health problem. Genetic factors and environmental factors jointly caused the development of gliomas, and understanding of the genetic basis is a key component of preventive oncology. However, most genetic factors underlying carcinogenesis of gliomas remain largely unclear. In current study, we systematically evaluated whether genetic variants of SOX9 gene, a transcription factor that plays a central role in the development and differentiation of tumors, contribute to susceptibility of gliomas among Chinese population using a two-stage, case–control study. Results showed that SOX9 rs1042667 was significant associated with increased gliomas risk after adjusted by age, gender, family history of cancer, smoking status and alcohol status (Allele C vs A: OR=1.25; 95% CI=1.11-1.40; P=1.2×10−4). Compared with the carriers of genotype AA, both those of genotype AC (OR=1.37; 95% CI=1.13-1.66) and CC (OR=1.53; 95% CI=1.22-1.91) had significantly increased gliomas risk. This should be the first genetic association study which aims to evaluated the association between genetic variants of SOX9 and susceptibility of gliomas. Additional functional and association studies with different ethnic groups included are needed to further confirm our results.