A study of the prevalence of osteoporosis and hypovitaminosis D in patients with primary knee osteoarthritis.
A study of the prevalence of osteoporosis and hypovitaminosis D in patients with primary knee osteoarthritis.
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DOI：
10.1016/j.jcot.2014.09.002
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发表时间：
2014-12-01
影响因子：
--
通讯作者：
Ghosh, Alakendu
中科院分区：
文献类型：
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作者：
Ghosh, Biswadip;Pal, Tanmoy;Ghosh, Alakendu
前言：骨关节炎和骨质疏松症是高发疾病，维生素D缺乏症也是高发疾病。我们试图了解原发性膝关节骨关节炎患者骨质疏松症和维生素D缺乏症的患病率。我们还比较了普通人群和原发性骨关节炎患者骨质疏松症的患病率。方法：选取印度加尔各答医学院医院风湿病科门诊和SSKM医院原发性膝关节OA患者。每个患者的年龄和性别相匹配的朋友或亲属在研究中作为对照。本研究以来自不同州的医院工作人员为对照。对照人群是一般人群的代表。结果：本研究共纳入受试者206人。其中98例病例和108例对照。骨密度状况与原发性OA显著相关。血清维生素D3水平与骨关节炎显著相关。患者的年龄与骨密度状态和膝关节关节炎有显著相关性，但与维生素D水平无显著相关性。血清维生素D3水平与骨密度有显著相关性。结论：骨质疏松症在普通人群和膝关节骨性关节炎患者中普遍存在，并可能增加其致残性。维生素D缺乏症在人群中也很普遍，并且与骨质疏松症和骨关节病呈正相关，这一事实使问题变得复杂，尽管由于研究的横断面设计，我们不能对进一步的发病机制发表评论。
INTRODUCTION: Osteoarthritis and Osteoporosis are highly prevalent disease, so is hypovitaminosis D. We tried to find out prevalence of osteoporosis and hypovitaminosis D in patients suffering from primary knee Osteoarthritis. We also compared the prevalence of oseotoporosis between general population and patients of primary osteoarthritis.METHODS: Patients suffering from primary knee OA were taken from Rheumatology OPD of Medical College Hospital and SSKM Hospital Kolkata, India. For each patient age and sex matched friend or relative of same locality was taken in the study as controls. Hospital staffs that come from different part of state was taken in the study as controls. The control population was the representative of general population.RESULTS: Total number of participants in this study was 206. Out of which there were 98 cases and 108 controls. BMD status correlates significantly with Primary OA. Serum Vitamin D3 status correlates significantly with Osteoarthritis. Age of the patients correlated significantly with both BMD Status and Knee OA but not with the vVitamin D level. There were significant correlation between the Serum Vitamin D3 status and BMD of the subjects.CONCLUSION: Osteoporosis is prevalent both in general population and patients suffering from Knee Osteoarthritis and may increase the disability. The matter is complicated by the fact hypovitaminosis D is also prevalent in the population and positively correlated with both Osteoporosis and osteoarthrosis, though we cannot comment on further pathogenesis because of cross sectional design of the study.