Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues
Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues
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DOI：
10.3727/000000006783981080
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Moriuchi, Tetsuya
中科院分区：
文献类型：
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作者：
Hassan, Nur Mohammad Monsur;Hamada, Jun-ichi;Moriuchi, Tetsuya
人类HOX基因由39个基因组成，编码作为主要发育调节因子的转录因子。我们假设错误的表达。HOX基因的缺失与肿瘤的发生和恶性进展有关。应用实时荧光定量RT-PCR方法检测31例口腔鳞癌、11例不典型增生和10例正常口腔黏膜组织中39个HOX基因的表达水平。18个HOX基因在SCC组织中的表达水平显著高于正常黏膜组织。异型增生组织中HOYA 2、A3、B3和D10的表达高于正常粘膜组织，而HOXA 1、B7、B 9和C8的表达低于SCC。有淋巴结转移的鳞癌组织中HOXC 6的表达明显高于无淋巴结转移的鳞癌组织，提示HOX基因的异常表达可能与口腔粘膜异型增生和鳞癌的发生发展有关。
Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression. of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOYA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.